Overview

  • Product name

  • Description

    Goat polyclonal to PRDM9

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species

    Goat
  • Species reactivity


    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse PRDM9 aa 436-448 (internal sequence) (Cysteine residue). (NP_659058.2).
    Sequence:

    QEQHVDSQNKNDK


    Database link: Q96EQ9

  • Positive control

    • Mouse fetal brain lysates, NIH3T3 lysates.

Properties

Applications

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 103 kDa.

Preliminary experiments gave an approx 70kDa band in Mouse fetal brain lysates and in lysates of cell line NIH3T3 after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 97.8kDa according to NP_659058.2. The 70kDa band was successfully blocked by incubation with the immunizing peptide.

Target

  • Function

    Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase.
  • Sequence similarities

    Contains 14 C2H2-type zinc fingers.
    Contains 1 KRAB-related domain.
    Contains 1 SET domain.
  • Cellular localization

    Nucleus. Chromosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC 2.1.1.43 antibody
    • Histone lysine N methyltransferase PRDM9 antibody
    • Histone-lysine N-methyltransferase PRDM9 antibody
    • MEISETZ antibody
    • PFM6 antibody
    • PR domain containing 9 antibody
    • PR domain containing protein 9 antibody
    • PR domain zinc finger protein 9 antibody
    • PR domain-containing protein 9 antibody
    • PRDM 9 antibody
    • PRDM9 antibody
    • PRDM9_HUMAN antibody
    see all

References

ab178445 has not yet been referenced specifically in any publications.

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