Overview

  • Product name

    Prednisolone sodium phosphate, glucocorticoid
  • Description

    Water-soluble glucocorticoid
  • Biological description

    Water-soluble glucocorticoid. Anti-inflammatory agent. Orally active. Active in vitro and in vivo.
  • Purity

    > 98%
  • General notes

    Prednisolone is a derivative of cortisol and a metabolite of prednisone; it exhibits immunosuppressive and anti-inflammatory activities. Prednisolone activates glucocorticoid receptors and is clinically used to treat inflammatory and autoimmune disorders. In mononuclear cells from subjects with multiple sclerosis, prednisolone decreases expression of T-bet, IFNγ, and phosphorylated STAT1, decreasing lymphocyte apoptosis. Additionally, prednisolone delays the progression of Duchenne muscular dystrophy (DMD), altering muscle fiber types in vivo.

    This product is a white to off white powder.

  • CAS Number

    125-02-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Musson DG  et al. An in vitro comparison of the permeability of prednisolone, prednisolone sodium phosphate, and prednisolone acetate across the NZW rabbit cornea. J Ocul Pharmacol 8:139-50 (1992). Read more (PubMed: 1506755) »
  • Pimlott SJ & Addy M Evaluation of a method to study the uptake of prednisolone sodium phosphate from different oral mucosal sites. Oral Surg Oral Med Oral Pathol 60:35-7 (1985). Read more (PubMed: 3862011) »
  • Addy M & Thaw M In vitro studies into the release of chlorhexidine acetate, prednisolone sodium phosphate, and prednisolone alcohol from cold cure denture base acrylic. J Biomed Mater Res 16:145-57 (1982). Read more (PubMed: 7061533) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142456.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up