Pregnenolone-16alpha-carbonitrile, Cytochrome P-450 inducer (ab144545)

Overview

  • Product name

    Pregnenolone-16alpha-carbonitrile, Cytochrome P-450 inducer
  • Description

    Cytochrome P-450 inducer
  • Biological description

    Cytochrome P-450 inducer. Activates PCN1 transcription. Xenobiotic receptor (SXR)/pregane X receptor (PXR) ligand. Active in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    1434-54-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ma Y & Liu D Activation of pregnane X receptor by pregnenolone 16 a-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice. PLoS One 7:e38734 (2012). Read more (PubMed: 22723881) »
  • Marek CJ  et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J 387:601-8 (2005). Read more (PubMed: 15595924) »
  • Orans J  et al. The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. Mol Endocrinol 19:2891-900 (2005). Read more (PubMed: 15961506) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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