Overview

  • Product name

    Pregnenolone, neurosteroid
  • Description

    Endogenous steroid prohormone and neurosteroid. PXR agonist.
  • Biological description

    Endogenous steroid prohormone and neurosteroid. PXR agonist. Anxiolytic effects and prevents diet-induced insulin resistance in vivo.
  • Purity

    > 98%
  • CAS Number

    145-13-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[(3S,8S,9S,10R,13S,14S,17S)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
  • Molecular weight

    316.48
  • Molecular formula

    C21H32O2
  • PubChem identifier

    8955
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Perumal MB & Dhanasekaran S HIV associated dementia: role for neurosteroids. Med Hypotheses 78:672-4 (2012). Read more (PubMed: 22386322) »
  • Ma Y & Liu D Activation of pregnane X receptor by pregnenolone 16 a-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice. PLoS One 7:e38734 (2012). Read more (PubMed: 22723881) »
  • Bitran D  et al. Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum. Brain Res 850:217-24 (1999). Read more (PubMed: 10629767) »

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