Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EP47(EPR3972)] to Presenilin 1 + 2
- Reacts with: Species independent
Product nameAnti-Presenilin 1 + 2 antibody [EP47(EPR3972)]
Species reactivityReacts with: Species independent
Storage instructionsStore at -20°C.
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RelevanceAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.
Cellular localizationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface.
- AD 3 antibody
- AD4 antibody
- AD5 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab242283 has not yet been referenced specifically in any publications.