Anti-Presenilin 1 + 2 antibody [EP47(EPR3972)] (ab242283)

This fast track antibody is not yet fully characterized. It is subject to these terms and conditions.

Overview

  • Product name
    Anti-Presenilin 1 + 2 antibody [EP47(EPR3972)]
  • Description
    Rabbit monoclonal [EP47(EPR3972)] to Presenilin 1 + 2

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species
    Rabbit

Target

  • Relevance
    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.
  • Cellular localization
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface.
  • Alternative names
    • AD 3 antibody
    • AD4 antibody
    • AD5 antibody
    • Alzheimer disease 3 antibody
    • Alzheimer disease 4 antibody
    • FAD antibody
    • Presenilin 1 antibody
    • Presenilin 2 antibody
    • Presenilin1 antibody
    • PS1 antibody
    • PS2 antibody
    • PSEN1 antibody
    • PSEN2 antibody
    • STM2 antibody
    see all

References

ab242283 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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