• Product name
    Anti-Presenilin 2 antibody
    See all Presenilin 2 primary antibodies
  • Description
    Rabbit polyclonal to Presenilin 2
  • Host species
  • Specificity
    ab106351 does not cross react with other proteins.
  • Tested applications
    Suitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Pig
  • Immunogen

    Synthetic peptide corresponding to Human Presenilin 2 aa 319-334 (internal sequence).


    Database link: P49810

  • Positive control
    • Rat brain tissue lysate; MCF7, HeLa, SMMC, CEM whole cell lysates; Rat brain tissue.



Our Abpromise guarantee covers the use of ab106351 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa.
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr Use a concentration of 1 µg/ml.


  • Function
    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
  • Tissue specificity
    Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
  • Involvement in disease
    Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
    Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similarities
    Belongs to the peptidase A22A family.
  • Domain
    The PAL motif is required for normal active site conformation.
  • Post-translational
    Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
    Phosphorylated on serine residues.
  • Cellular localization
    Endoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AD3L antibody
    • AD3LP antibody
    • AD4 antibody
    • AD5 antibody
    • Alzheimer disease 4 antibody
    • CMD1V antibody
    • E5-1 antibody
    • OTTHUMP00000035671 antibody
    • OTTHUMP00000035672 antibody
    • OTTHUMP00000228286 antibody
    • OTTHUMP00000228288 antibody
    • Presenilin 2 (Alzheimer disease 4) antibody
    • Presenilin 2 antibody
    • Presenilin-2 CTF subunit antibody
    • PS-2 antibody
    • PS2 antibody
    • Psen2 antibody
    • PSN2_HUMAN antibody
    • PSNL2 antibody
    • STM-2 antibody
    • STM2 antibody
    see all


  • Immunohistochemical analysis of paraffin-embedded Rat Kidney tissue labeling Presenilin 2 with ab106351.

  • Immunohistochemical analysis of paraffin-embedded Rat Cardiac Muscle tissue labeling Presenilin 2 with ab106351.

  • Immunohistochemical analysis of paraffin-embedded Human Mammary Cancer tissue labeling Presenilin 2 with ab106351.

  • All lanes : Anti-Presenilin 2 antibody (ab106351) at 1 µg/ml

    Lanes 1-2 : Rat brain tissue lysate
    Lane 3 : MCF7 whole cell lysate
    Lane 4 : HeLa whole cell lysate
    Lane 5 : SMMC whole cell lysate
    Lane 6 : CEM whole cell lysate

    Predicted band size: 50 kDa

  • ab106351, at 1µg/ml, staining Presenilin 2 in frozen Rat brain tissue sections by Immunohistochemistry.


This product has been referenced in:
  • Xu TH  et al. Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to ?-secretase cleavage and the Aß42/Aß40 ratio. Cell Discov 2:16026 (2016). WB ; Human . Read more (PubMed: 27625790) »

See 1 Publication for this product

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