Overview

  • Product name

    Anti-Presenilin 2/AD5 antibody
    See all Presenilin 2/AD5 primary antibodies
  • Description

    Rabbit polyclonal to Presenilin 2/AD5
  • Host species

    Rabbit
  • Specificity

    ab106351 does not cross react with other proteins.
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Pig
  • Immunogen

    Synthetic peptide corresponding to Human Presenilin 2/AD5 aa 319-334 (internal sequence).
    Sequence:

    YDPEMEEDSYDSFGEP


    Database link: P49810

  • Positive control

    • Rat brain tissue lysate; MCF7, HeLa, SMMC, CEM whole cell lysates; Rat brain tissue.
  • General notes

    Previously labelled as Presenilin 2. 

Properties

Applications

Our Abpromise guarantee covers the use of ab106351 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 50 kDa.
IHC-P Use a concentration of 0.5 - 1 µg/ml.

Target

  • Function

    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
  • Tissue specificity

    Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
  • Involvement in disease

    Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
    Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similarities

    Belongs to the peptidase A22A family.
  • Domain

    The PAL motif is required for normal active site conformation.
  • Post-translational
    modifications

    Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
    Phosphorylated on serine residues.
  • Cellular localization

    Endoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AD3L antibody
    • AD3LP antibody
    • AD4 antibody
    • AD5 antibody
    • Alzheimer disease 4 antibody
    • CMD1V antibody
    • E5-1 antibody
    • OTTHUMP00000035671 antibody
    • OTTHUMP00000035672 antibody
    • OTTHUMP00000228286 antibody
    • OTTHUMP00000228288 antibody
    • Presenilin 2 (Alzheimer disease 4) antibody
    • Presenilin 2 antibody
    • Presenilin-2 CTF subunit antibody
    • PS-2 antibody
    • PS2 antibody
    • Psen2 antibody
    • PSN2_HUMAN antibody
    • PSNL2 antibody
    • STM-2 antibody
    • STM2 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Rat Kidney tissue labeling Presenilin 2 / AD5 with ab106351.

  • Immunohistochemical analysis of paraffin-embedded Rat Cardiac Muscle tissue labeling Presenilin 2 / AD5 with ab106351.

  • Immunohistochemical analysis of paraffin-embedded Human Mammary Cancer tissue labeling Presenilin 2 / AD5 with ab106351.

  • All lanes : Anti-Presenilin 2/AD5 antibody (ab106351) at 1 µg/ml

    Lanes 1-2 : Rat brain tissue lysate
    Lane 3 : MCF7 whole cell lysate
    Lane 4 : HeLa whole cell lysate
    Lane 5 : SMMC whole cell lysate
    Lane 6 : CEM whole cell lysate

    Predicted band size: 50 kDa

References

This product has been referenced in:

  • Xu TH  et al. Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to ?-secretase cleavage and the Aß42/Aß40 ratio. Cell Discov 2:16026 (2016). WB ; Human . Read more (PubMed: 27625790) »
See 1 Publication for this product

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