Overview

  • Product name

  • Description

    Rabbit polyclonal to PREX1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human PREX1 aa 982-1185. The exact sequence is proprietary.
    Database link: Q8TCU6

  • Positive control

    • THP1 whole cell lysate; 293T cell lysate transfected with PREX1.

Properties

Applications

Our Abpromise guarantee covers the use of ab183643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 186 kDa.

Target

  • Function

    Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
  • Tissue specificity

    Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
  • Sequence similarities

    Contains 1 DEP domain.
    Contains 1 DH (DBL-homology) domain.
    Contains 1 PDZ (DHR) domain.
    Contains 2 PH domains.
  • Cellular localization

    Cytoplasm > cytosol. Cell membrane. Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 4 antibody
    • 5)-dependent Rac exchanger 1 antibody
    • KIAA1415 antibody
    • OTTHUMP00000031228 antibody
    • P REX1 antibody
    • P Rex1 protein like antibody
    • P-Rex1 antibody
    • Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchange factor 1 antibody
    • Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1 antibody
    • Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1 protein antibody
    • Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein antibody
    • Prex1 antibody
    • PREX1_HUMAN antibody
    • PtdIns(3 antibody
    • PtdIns(3,4,5) dependent Rac exchanger 1 antibody
    • SET domain containing 6 antibody
    • Setd6 antibody
    see all

Images

  • All lanes : Anti-PREX1 antibody (ab183643) at 1/10000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : 293T transfected with PREX1 whole cell lysate

    Lysates/proteins at 1 µg per lane.

    Predicted band size: 186 kDa



    5 % SDS-PAGE

  • Anti-Mycobacterium tuberculosis 16kDa antibody [HTM61] (ab183164) at 1/1000 dilution + THP1 whole cell lysate at 30 µg

    Predicted band size: 186 kDa



    5 % SDS-PAGE

References

ab183643 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab183643.
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