Product namePRIMA-1MET, p53 activity
DescriptionRestores mutant p53 activity
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Peng X et al. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis 4:e881 (2013). Read more (PubMed: 24157875) »
- Stuber G et al. PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol Cancer 8:23 (2009). Read more (PubMed: 19323829) »
- Shen J et al. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27:6571-80 (2008). Read more (PubMed: 18663359) »
- Bykov VJ et al. PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. Oncogene 24:3484-91 (2005). Read more (PubMed: 15735745) »