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We provide comprehensive solutions for custom antibody development, with the ability to go from initial target evaluation through to delivery of purified fit-for-purpose antibody for research, diagnostic or therapeutic application.
We have highly experienced teams dedicated to antibody discovery for custom projects. We design and execute tailor-made discovery and selection strategies to generate and select binders that meet your desired antibody specifications.
We will utilize the most appropriate technology dependent upon the target of interest, antibody requirements, and customer timelines.
We have comprehensive antibody discovery platforms that we deploy as required to achieve the goal of each custom antibody discovery program.
The unique features of the rabbit immune system make it ideal for antibody generation, particularly to challenging targets. Rabbits generate an expansive B-cell repertoire due to reliance on a gene-conversion mechanism in concert with somatic hypermutation during B-cell development.
The rabbit’s immune system supports the generation of a diverse selection of antibodies that can differentiate between even the most subtle structural variants, such as post-translational modifications, point mutations, and epigenetic targets. The diverse epitope recognition found in the rabbit also helps in identifying high-sensitivity antibody pairs. Additionally, rabbits possess a single subclass of IgG, removing the need for isotyping and allowing direct comparison of candidates at an early stage in screening cascades.
RabMAb antibody discovery
If an in vivo approach to antibody generation can’t be used, e.g., the target is toxic or non-immunogenic, we can combine our phage display technology with our other antibody discovery platforms to generate highly sensitive and specific antibodies for your needs.
In addition to selecting the optimum antibody discovery platform (or combination of platforms), tailor-made assay cascades are designed for each custom antibody discovery project.
Our assay cascades detail the screens and any application-specific tests that will be executed to ensure identification of the best antibody for your specific requirements in terms of selectivity, sensitivity and application performance.
(including but not limited to)
All our custom antibodies are sequenced, cloned, and produced in a recombinant system. This ensures high antibody yields, batch-to-batch consistency, and sustainable long-term supply.
In the IVD space, we have agreements in place with several leading IVD manufacturers, that enable us to act as a single point of contact to transition reagents from research onto multiple IVD platforms.
Our RabMAb antibody manufacturing site is ISO 9001:2015 certified and all other sites work to these standards.
Our In Vitro Diagnostics (IVD) group is registered with the USFDA and operates under USFDA Quality System Regulation (21 CFR Part 820) and in compliance with ISO 13485:2016. This facility and its quality system have a Medical Device Manufacturing License granted by the California Department of Public Health (CDPH).
The timelines for custom antibody development are dependent upon the complexity of each project and the technological and engineering requirements needed to identify an antibody that meets the specific end-user needs.
The approximate timeframes for antibody development and delivery of a purified antibody are in the range of 5-9 months, including NGS services, with indications of success from as early as 2 months.
We routinely work with a wide variety of immunogens including
The costs for custom-antibody generation are dependent upon project requirements.
A costed proposal is developed on a case-by-case basis and will be discussed with you before the project starts.
For some customers, it can be beneficial to have their specific reagent validated by our global customer base and it is possible to agree commercial terms that will allow the reagent to be included in our portfolio for Research Use Only.
We can support antibody and assay development to a GMP-ready position and then work with you to transfer your antibody to a partner for GMP manufacture. We can also support GMP manufacture for use in immunohistochemistry.
Following discovery, if appropriate, we can support a variety of antibody engineering options, including:
Several RabMAb antibodies have been successfully humanized for therapeutic use. We work with a partner organization to carry out humanization on a case by case basis.
We also support CDR grafting to selected frameworks, using phage display as an intermediate to confirm engineered Ab performance.
*Subject to commercial terms and conditions. Please contact email@example.com for more information.