Effector T cell markers
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Accurately phenotype human effector T cell subsets with the best markers.
So that you can quickly and accurately find the most relevant markers for immunophenotyping human effector T cells, we've compiled markers from the literature into a detailed poster. The poster includes
- A summarized T cell differentiation lineage
- Surface and secreted markers
- Transcription factor markers
| Cell type | Surface markers | Secreted markers | Transcription factor markers |
| Naïve CD4+ T cell | CD4+, CD45RA+, CD45RO-, CCR7+ | ||
| Th1 cell | CD4+, CXCR3+, CCR5+, IL12Rβ2+ | IFN-γ+ | T-bet+ |
| Th2 cell | CD4+, CCR4+, IL12Rβ2- | IL-4+, IL-5+ | GATA3+ |
| Th9 cell | CD4+, CCR3+, CCR6+ | IL-9+ | PU.1/Spi1+ |
| Th17 cell | CD4+, CCR6+, CCR4+, NK1.1+ | IL-17+ | |
| Th22 cell | CD4+, CCR10+, CCR4+, CCR6+ | IL-22+ | |
| Treg cell | CD4+, CD127+, CD25+, CTLA-4+ | IL-2+ | FOXP3+ |
| Tfh cell | CD4+, CXCR5+, CD40L+, ICOS+ | IL-21+ | Bcl-6+ |
| γδ T cell | TCRγ/δ+, IL23R+ | IL-17+ | RORγt+ |
| NKT cell | TCR Vα24+, TCR Vβ11+ | IFN-γ+, IL-4+ | |
| Naïve CD8+ T cell | CD8+, CD45RA+, CD45RO-, CCR7+, CD28+ | IFN-γ+, IL-2+ | |
| Cytotoxic CD8+ T cell | CD8+, CCR7- | IFN-γ+, Perforin+, Granzyme+ |
For additional cell types, take a look at our immune cell markers poster where you can easily select myeloid and lymphoid lineage-specific markers for both human and mouse.
References