Antibodies for Parkinson's disease targets

Get to the root of Parkinson's disease with rabbit monoclonal antibodies for key disease targets.

To provide the tools you need for Parkinson’s disease research, we partnered with The Michael J. Fox Foundation (MJFF) to develop rabbit monoclonal antibodies for leucine-rich repeat kinase 2 (LRRK2), alpha-synuclein, DJ-1, RAB8A, and RAB10.

We've put together a video to showcase what the partnership means for the advancement of future Parkinson's disease research breakthroughs. Watch the video here.

About The Michael J. Fox Foundation

MJFF is dedicated to finding a cure for Parkinson's disease through an aggressively funded research agenda and to ensuring the development of improved therapies for those living with Parkinson's today.

Learn more about The Michael J.Fox Foundation.


LRRK2 gene mutations are the most common cause of inherited Parkinson's disease. While it is the focus of intensive research in the Parkinson's field, a lack of high-quality LRRK2 antibodies has been a major roadblock to the successful development of LRRK2-based therapies.

After primary characterization organized by MJFF and feedback from the Parkinson’s disease research community, three rabbit monoclonal clones exhibiting the best performance were selected for distribution via Abcam.

"LRRK2 antibodies are critical to help move Parkinson's research forward. The three unique clones chosen for initial release were identified based on several months of testing by our large network of PD researchers... we are excited that they [Abcam] will continue to help MJFF remove barriers to developing Parkinson's therapies."

- Dr. Mark Frasier, Vice President of Research Programs at MJFF

LRRK2 antibodies

Antibody nameClone IDApplicationsSpeciesAbID
ICC/IF, IHC-FrFl, IHC-P, IP, WB Hu, Ms, Rtab133474
ICC/IF, IHC-P, IP, WBHu, Ms, Rtab133475
ICC/IF, IHC-P, IP, WBHu, Ms, Rtab133476
MJFF5 (68-7)WBHu, Msab181386
LRRK2UDD3 30(12)ICC/IF, IHC-P, WBHu, Msab133518
(phospho S910)
UDD1 15(3)WBHuab133449
(phospho S935)
UDD2 10(12)ICC/IF, WBHu, Msab133450
LRRK2 (phospho S955)MJF-R11 (75-1)WBHu, Msab169521
LRRK2 (phospho S973)MJF-R12 (37-1)WBHuab181364
LRRK2 (phospho T1410)MJFR4-25-5WBHu, Ms, Rtab140107
(phospho T1491)

LRRK2 (phospho T1503)

LRRK2 (phospho S1292)MJFR-19-7-8WBHuab203181
LRRK2 (phospho T2483)MJF-R8

​​​See a complete list of LRRK2 antibodies and their characterization data.


Alpha-synuclein was the first gene to be linked to Parkinson’s disease and remains the most promising link to Parkinson's pathogenesis. Alpha-synuclein is a major component of Lewy bodies, a type of intraneuronal aggregate. Build up of these aggregates within neurons causes the loss of motor control associated with Parkinson's disease. 

Synuclein antibodies

Antibody nameClone IDApplicationsSpeciesAbID
Alpha-synucleinMJFR1ELISA, Flow Cyt, ICC/IF, IHC-P, IP, WBHu, Drosophila melanogasterab138501
Alpha-synuclein (phospho S129)MJF-R13
Alpha synuclein filament - conformation specificMJFR-14-6-4-2ICC/IF, IHC-P, dot blotHu, Ms, Rtab209538


DJ-1 (PARK7) is thought to act as a sensor of oxidative stress in cells. It has increasingly been investigated for modifications that occur as a result of disease pathogenesis, including protein oxidation. DJ-1 is responsible for the activation of microglia leading to neuroinflammation associated with Parkinson's disease. 

DJ-1 antibody

Antibody nameClone IDApplicationSpeciesAbID

Rab8A and Rab10

Certain Rab GTPases (Rabs) modulate α-synuclein and impairment of these proteins constitutes one of the rare causes for inherited early-onset Parkinson's disease. Rab8 and Rab10 specifically aid in trafficking glucose transporter type 4 (GLUT4) to the plasma membrane. 

Rab antibodies

Antibody nameClone IDApplicationSpeciesAbID

Anti-RAB8A (phospho T72)


WB, Dot blotMo, Hu


Anti-RAB10 (phospho T73)


WB, Dot blotMo, Hu



[MJF-22-74-3]WB, IPMo, Rt, Huab237702

[MJF-23-32-5]IP, Flo Cyt, ICC/IF, WBMo, Rt, Huab237703
Anti-RAB10 (phospho T73)

[MJF-R21-22-5]WB, Dot Blot, ICC/IFMo, Huab241060
Anti-RAB29 (phospho T71)
[MJF-R24-17-1]Dot Blot, WBHuab241062

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