Human CD markers chart

List and summary of all human CD antigens from CD1a to CD371.

Updated August 5, 2021

The cluster of differentiation (CD) is a nomenclature system conceived to identify and classify antigens found on the cell surface of leukocytes. Initially, surface antigens were named after the monoclonal antibodies that bound to them. As there were often multiple monoclonal antibodies raised against each antigen in different labs, the need arose to adopt a consistent nomenclature. The current system was adopted in 1982 through the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA). The Human Cell Differentiation Molecules organization continues to hold HLDA conferences to maintain and develop the list of known CD markers.

Under this naming system, antigens that are well characterized are assigned an arbitrary number (eg CD1, CD2 etc) whereas molecules that are recognized by just one monoclonal antibody are given the provisional designation “CDw” eg CDw50. Lower class letters are also added after the assigned number to indicate larger molecules that share a common chain, for example CD1a or CD1d. Physiologically, CD molecules do not belong in any particular class, with their functions ranging widely from cell surface receptors to adhesion molecules. Although initially used just for human leukocytes, the CD molecule naming convention has now been expanded to cover different species (eg mouse) as well as other cell types. As of April 2016, human CD antigens are numbered up to CD371.

The presence or absence of a specific antigen from the surface of a particular cell population is denoted with “+” or “-" respectively. Varying cellular expression levels are also marked as hi or low, for example central memory T-cells are CD62Lhi whereas effector memory T-cells are CD62Llow. Monitoring the expression profiles of different CD antigens has permitted the identification, isolation and phenotyping of cell types according to their function in various immune processes.

Use the table below to find your target of interest, with corresponding information from relevant scientific literature and the Human Cell Differentiation Molecules (HCDM) organization. Select a target name to find related products.

Download your human CD antigen guide pdf.

Jump to: CD100 | CD200 | CD300a

Target Name	Alternative name(s)	Expression	Functions
CD1a	-	Cortical thymocytes, Langerhans cells, dendritic cells and certain T-cell leukemias.	Mediates the presentation of lipid and glycolipid antigens to T-cells.¹
CD1b	-	Cortical thymocytes, Langerhans cells and dendritic cells.	Non-peptide antigen presentation to T-cell receptors on NKT cells.¹
CD1c ³	-	Cortical thymocytes, Langerhans cells, dendritic cells and B-cell subsets.
CD1d	R3G1	Intestinal epithelial cells, B-cell subsets, cortical thymocytes, dendritic cells and certain T-cell leukemias.
CD1e	R2G1, HSCDIEL	Cortical thymocytes, Langerhans cells, dendritic cells and certain T-cell leukemias.	Non-peptide antigen presentation.¹
CD2	SRBC, T11	Natural killer cells, T- and B-cells, monocytes/ macrophages, dendritic cells.	T-cell activation. Adhesion between T-cells and other cell types. Triggers potent proximal T-cell signaling response. Regulates allergic airway inflammation.⁴
CD3d	T3D, OKT3	Invariant chain expressed on mature T-cells and thymocytes.	T-cell development⁵ and signal transduction.
CD3e ⁶	T3E, TCRE	Mature T-cells and thymocytes.	T-cell activation signaling and regulation of TCR expression. Partakes in the formation and function of TCR-CD3 complex to couple antigen recognition to intracellular signaling pathways.
CD3g ⁷	T3G	Mature T-cells and thymocytes.	Partakes in the formation and function of TCR-CD3 complex to couple antigen recognition to intracellular signaling pathways.
CD4 ⁸	-	Thymocyte subsets, T-helper cells, regulatory T-cells, B-cells, macrophages and granulocytes.	Initiates the early phase of T-cell activation. May function as an important mediator of indirect neuronal damage in infectious and immune-mediated CNS diseases.
CD5	LEU1, T1	T-cells and B-cell subset.	Regulates T-cell: B-cell interactions. Inhibits TCR-mediated signaling.⁹
CD6	OX52, T12, TP120	Thymocytes, mature T-cells, some hematopoietic cell precursors, neuron subsets, B-cell and NK subsets.	Acts in stabilization and maturation of the immune synapse, and in T-cell proliferative responses.¹⁰
CD7	LEU 9, GP40, TP41, Tp40	Thymocytes and mature T-cells. High expression in T-cells.	Essential in T-cell interaction, as well as in T-cell: B-cell interaction during early lymphoid development.
CD8a ^{12, 13}	MAL, Leu2, p32	Cytotoxic T-cells, natural killer cells, cortical thymocytes and dendritic cells subsets.	Mediates efficient cell: cell interactions within the immune system.
CD8b ¹³	CD8B1, LYT3, Leu2, Ly3	Thymocyte subsets and cytotoxic T-cells.	Co-receptor for MHC class 1 molecules.
CD9	MIC3, BA2, DRAP-27, MRP-1	Platelets, pre-B-cells, eosinophils, basophils, activated T-cells, oocytes and myoblasts.	Cell invasion, apoptosis and resistance to chemotherapy.¹⁴
CD10	Neprilysin, CALLA, SFE, MME, NEP	B- and T-cell precursors, fibroblasts, neurons and bone marrow stromal cells.	Peptidase, regulates B-cell growth. Upon upregulation, involved in cell proliferation, angiogenesis, and apoptosis resistance.¹⁵
CD11a	Integrin alpha-L, LFA-1A, ITGAL	Leukocytes, lymphocytes, granulocytes, monocytes and macrophages. Expressed in nearly all hematopoietic lineages, but downregulated on HSCs.¹⁶	Intracellular adhesion and costimulation. Binds with CD18 to form LFA1, which then interacts with ICAM-1.
CD11b	Integrin alpha-M, CR3A, ITGAM, MAC-1	Macrophages, T-cells and myleoid dendritic cells.	Regulates macrophage polarization, inhibits immune suppression, modulates neovascularization and cancer.¹⁷
CD11c	Integrin alpha-X, ITGAX, SLEB6	Monocytes, macrophages, granulocytes, dendritic cells, NK cells, activated T- and B-cells, T- and B-cell subsets.	Cell adhesion. Gatekeeper for lymphocyte trafficking.¹⁹
CD11d ¹⁹	Integrin-alpha-D, ADB2, ITGAD	Myelomonocytic cells, peripheral blood leukocyte subsets and tissue-specialized cells	Receptor for ICAM3 and VCAM1 when bound with CD18. May play a role in the atherosclerotic process and phagocytosis of blood-borne pathogens. ²⁰
CD13	ANPEP, APN, PEPN, LAP1, gp150	Granulocytes, monocytes (+ precursors), endothelial cells and epithelial cells.	Phagocytic receptor capable of mediating the internalization of large particles.
CD14	-	Dendritic cells, monocytes and macrophages.²²	Receptor for LPS and LBP complex.
CD15	ELFT, FCT3A, FUC-TIV	Myeloid cells: neutrophils, eosinophils, some monocytes, masked on basophils.	Cell adhesion. Mediates phagocytosis and chemotaxis. Involved in leukocyte homing, and adhesion of cancer cells to brain endothelium.²³ Mediates neutrophil adhesion to dendritic cells.
CD16a	Fc-gamma RIII-alpha, FCGR3A, FCG3, FCGR3, IGFR3	Neutrophils, natural killer cells, monocytes and macrophages.	Mediates phagocytosis and ADCC. Low affinity Fc receptor.^{24, 25}
CD16b	Fc-gamma RIII-beta, FCGR3B, FCG3, FCGR3, IGFR3	Neutrophils and stimulated eosinophils.	Low affinity Fc receptor.
CD17	Lactosylceramide	Monocytes/macrophages, platelets, B-cell subsets, granulocytes, tonsillar dendritic cells and platelets.	Lactocyl ceramide. Cell surface glycosphingolipid. May play a role in bacterial phagocytosis.
CD18 ²⁶	Integrin beta-2, ITGB2, MFI7, LAD, LCAMB, LFA-1	Neutrophils, monocytes, macrophages.	Forms the beta 2 chain of CD11a-c enabling cell adhesion.
CD19 ²⁷	B-lymphocyte surface antigen B4, MGC12802, CVID3	B-cells (but not plasma cells) and follicular dendritic cells.	Regulates B-cell development, activation and differentiation. Coreceptor for BCR, activates signaling pathways.
CD20 ²⁸	B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, MS4A2	T- and B-cell subsets.	B-cell activation and proliferation. Development and differentiation of B-cells into plasma cells.
CD21 ²⁹	Complement receptor type 2, CR2, C3DR, Complement C3d receptor, Epstein-Barr virus receptor	Mature B-cells, follicular dendritic cells and T-cell subsets.	Signal transduction. Receptor for complement components C3Dd and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220.
CD22 ³⁰	SIGLEC2, BL-CAM, T-cell surface antigen Leu-14	Mature B-cells (except plasma cells).	B-cell adhesion and signal transduction. May help localize B-cells in lymphoid tissue
CD23 ³¹	Low affinity immunoglobulin epsilon Fc receptor, Fc epsilon RII, FCER2, CLEC4J	Mature B-cells, monocytes, follicular dendritic cells, platelets and eosinophils.	Low affinity receptor for IgE, ligand for CD19, CD21 and CD81. Essential for B-cell growth and differentiation. In soluble form, functions as mitogenic growth factor.
CD24	CD24A	B-cells, granulocytes, epithelial cells and monocytes.	Regulation of B-cell proliferation and differentiation.³²
CD25 ³³	Interleukin-2 receptor subunit alpha, IL2RA, TAC antigen, TCGFR	Activated T-cells, some thymocytes, regulatory T-cells and oligodendrocytes.	Receptor for IL2 in complex with CD122 and CD132.
CD26	DPP4, ADABP, ADCP2, DPPIV, TP103	Mature thymocytes, T-cells (upregulated on activation), activated B-cells and high Th17.	Exoprotease. HIV pathogenesis. Highly expressed in inflammatory diseases. Controls migration of CD4+ T-cells.³⁴
CD27	TNF receptor superfamily member 7, TNFRSF 7, CD27L receptor, T14, MGC20393, S152, Tp55	T-cells, medullary thymocytes, B-cells and NK cells.	Costimulation of B- and T-cell activation upon binding to ligand CD70.³⁵ Crucial for T-cell memory generation.
CD28	TP44	Most T-cells, thymocytes, plasma cells, stromal cells, neutrophils and eosinophils.	Costimulation of T-cells. Induces T-cell activation and survival, interleukin-2 production, T-helper type 2 cell development and clonal expansion.³⁶
CD29	Integrin beta-1, ITGB1, Fibronectin receptor subunit beta, FNRB, GPIIA, MDF2, MSK12, VLAB	Leukocytes, adipose-derived stem cells and BM-MSCs.	Interacts with CD49a in VLA-1 integrin. Mediates cell interactions with extracellular matrix proteins. Controls tumor proliferation, survival, angiogenesis and metastasis.³⁷
CD30	TNF receptor superfamily member 8, TNFRSF8, Ki-1 antigen, D1S166E	Activated T- and B-cells, monocytes, Reed-Sternberg cells and T-cell lymphomas	Regulates lymphocyte proliferation and cell death. Critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas.³⁸
CD31	Platelet endothelial cell adhesion molecule, PECAM1	Monocytes, platelets, T-cells, neutrophils and endothelial cells.³⁹	Cell adhesion. Plays a key role in removing aged neutrophils.
CD32 ⁴⁰	Fc gamma RII, FCGR2A, FCGR2B, FCGR2C	B-cells, platelets, Langerhans cells, neutrophils, megakaryocytes and monocytes.	FcgRIIA are activating-type Fc receptors, while FCGRIIB is a key immune checkpoint.⁴¹All act as receptors for immunoglobulins.
CD33	p67, Sialic acid-binding Ig-like lectin 3 (SIGLEC3)	Normal myeloid cell progenitors, activated T-cells and NK cells.⁴²	Lectin activity and adhesion. A receptor that inhibits the proliferation of normal, leukemic myeloid and lymphoid cells.⁴³
CD34 ⁴⁴	-	Hematopoietic stem cells and progenitors and capillary endothelial cells.	Major vascular selectin ligand – necessary for the first step of cell migration.⁴⁵
CD35	Complement receptor type 1, C3BR	Erythrocytes, leukocytes, glomerular podocytes, hyalocytes and splenic follicular dendritic cells.	Receptor for complement components C3b and C4b.⁴⁶ Mediates adhesion and phagocytosis.
CD36	Fatty acid translocase, Glycoprotein IIIb, GP3B, GP4, GPIV, PASIV, SCARB3	Found on many cells and tissues; intestine, adipose tissue, heart, skeletal muscle and macrophages.	Facilitates tissue fatty acid uptake and oxidation.⁴⁷ Involved in signal transduction in immunity and atherosclerosis. High affinity receptor for native lipoproteins HDL, LDL and VLDL.
CD37 ^{48, 49}	Tetraspanin 26, TSPAN26, GP52-40	Mature B-cells and myeloid cells.	Signal transduction. Regulates T-cell proliferation. Involved in the spatial organization of B-cell plasma membrane.
CD38	ADP ribosyl cyclase 1, NAD(+) nucleosidase	T-cells, B-cells and NK cells.	Regulates intracellular and extracellular NAD homeostasis. Regulates NAD-dependent deacetylases related to aging.⁵⁰
CD39 ⁵¹	NTPDase 1, TPDase	Fibroblasts, myeloid cells, vascular endothelial cells, Tregs and tumor-specific T-cells.	Hydrolyzes extracellular ATP, high levels found in tumors which deplete immunostimulatory ATP.
CD40 ⁵²	Bp50, p50	B-cells, monocytes, macrophages, endothelial cells, T-cells and CNS-resident cells.	Costimulation of B-cell growth. Differentiation and isotype switching. With CD40L, plays a key role in the pathogenesis of autoimmune disease⁵³, regulates sympathetic axon growth, and establishes innervation of certain tissues in developing PNS.
CD41 ⁵⁴	Integrin alpha-IIb, GPalpha IIb, ITGA2B, GP2B, GTA	Platelets and megakaryocytes.	Platelet activation and aggregation.
CD42a ⁵⁵	Platelet glycoprotein IX, GP9		Platelet adhesion and aggregation. Amplifies platelet response to thrombin.
CD42b ⁵⁶	Platelet glycoprotein Ib alpha chain, BSS, GP1B		Platelet adhesion and aggregation.
CD42c ⁵⁷	Platelet glycoprotein Ib beta chain, GP1BB
CD42d	Platelet glycoprotein V, GP5
CD43 ⁵⁸	Leukosialin, Galactoglycoprotein, Leukocyte sialoglycoprotein, SPN, GPL115, LSN	Leukocytes (except resting B-cells).⁵⁹Low expression in platelets.	Anti-adhesion. Binds CD45 to mediate adhesion. Important for immune function and may be part of receptor complex for T-cell activation.
CD44 ⁶⁰	Epican, HUTCH-I, LHR, PGP-1, ECMR-III, IN, INLU, MC56, MDU2, MIC4, MUTCH-1	Most lymphohematopoietic cells.	Leukocyte rolling, homing and aggregation. Adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. Important in epithelial cell adhesion (cell-cell and cell-matrix) to hyaluronate in basement membranes and maintaining the polar orientation of cells.
CD45 ⁶¹	Leukocyte common antigen, L-CA, PTPRC	Hematopoietic cells (not erythrocytes and platelets).	Critical for B- and T-cell receptor-mediated activation. Also required for thymic selection.
CD45RA ⁶²	PTPRC	B- and naïve T-cell subsets, monocytes and medullary thymocytes.
CD45RB		T-cell subsets, B-cells, monocytes, macrophages, granulocytes, dendritic cells and natural killer cells.	Critical for B- and T-cell receptor mediated activation.
CD45RC ⁶³		B-cells, natural killer cells, CD8+ T-cells, CD4+ T-cell subsets, medullary thymocytes, monocytes and dendritic cells.
CD45RO ⁶²		Activated T-cell subsets, memory B- and T-cell subsets, activated monocytes/macrophages and granulocytes.
CD46	Membrane cofactor protein, TLX, MCP, TRA2.10	Ubiquitous: found on all nucleated human cells.⁶⁴	Co-factor for factor 1 proteolytic cleavage of C3b and C4b. Protects against inappropriate complement activation. Controls T-cell activation.
CD47	Integrin associated protein, MER6, OA3	Ubiquitous: expressed by virtually every cell.	Adhesion. A marker of self that binds to SIRP alpha inhibitor receptor on macro and dendritic cells to inhibit phagocytosis. Regulates chemotaxis and activation of leukocytes. Can induce apoptosis.⁶⁵
CD48	BLAST1, BCM1, MEM-102, SLAMF2	Most hematopoietic cells.	Cell adhesion and T-cell costimulation. Expression increases under inflammatory conditions. Target of immune evasion by viruses.⁶⁶
CD49a	Integrin alpha-1, VLA-1, ITGA1	Activated T-cells, monocytes, melanoma cells and endothelial cells.	Adhesion and embryo development. Involved in T-cell mediated inflammatory disease.⁶⁷
CD49b	Integrin alpha-2, VLAA2, BR, ITGA2	Tregs⁶⁸, mature NK cells and subsets of memory CD4+ T-cells.	Suppresses naïve T-cell proliferation. Migrates to sites of inflammation and skin.
CD49c ⁶⁹	Integrin alpha-3, VLA-3 subunit alpha, ITGA3, GAPB3, MSK118, VCA-2	Most adhesion cell lines. Low expression on B- and T-cells.	Adhesion and signal transduction. Matrix degradation to promote cell invasion.
CD49d	Integrin alpha-4, VLA-4 subunit alpha, ITGA4	Leukocytes, neutrophils.	Involved with retention and release of neutrophils.⁷⁰ Critical role in leukocyte trafficking, activation and survival.
CD49e ⁷¹	Integrin alpha-5, VLA-5, ITGA5, FNRA	Thymocytes, T-cells, monocytes, platelets, early and activated B-cells, endothelial cells and epithelial cells.	Adhesion, regulation of cell survival and apoptosis. Receptor for fibronectin and fibrinogen.
CD49f ⁷²	Integrin alpha-6, VLA-6, ITGA6	Memory B-cells, T-cells, thymocytes, monocytes, platelets, megakaryocytes, epithelial cells, endothelial cells and cytotrophoblasts.	Present in oocytes, involved in sperm-egg fusion. Receptor for laminin on platelets.
CD50	ICAM3, CDw50, ICAM-R	Leukocytes, with high expression on peripheral blood granulocytes, monocytes and lymphocytes.	Binds to LFA-a protein.⁷³ Important in leukocyte recruitment, apoptotic cell removal and lymphocyte interaction with APCs.
CD51	Integrin alpha chain V, ITGAV, MSK8, VNRA	Mesenchymal stem/stroma cells.⁷⁴	Adhesion and signal transduction.
CD52 ⁷⁵	Campath-1	B- and T-cells, monocytes, macrophages, eosinophils, NK cells, dendritic cells and epithelial cells of epididymis.	Glycosylphosphatidylinositol (GPI) anchored antigen which may play a role in carrying and orienting carbohydrate.
CD53	MOX44	Hematopoietic cells and highly expressed on mature B-cells	Signal transduction. B-cell activity modulation.⁷⁶
CD54	ICAM1, BB2	Endothelial cells, low expression on resting lymphocytes, upregulated upon activation, and expressed in many tumor types.	Extravasation of leukocytes from blood vessels. Regulates T-cell activation. Involved in tumorigenesis of various cancers.⁷⁷
CD55 ⁷⁸	Complement decay accelerating factor, DAF, CR, TC	Epithelial cells and all cells that are in close contact with plasma complement proteins.	Regulates complement activation. Ligand or protective molecule in fertilization. Signal transduction.
CD56 ⁷⁹	NCAM1, MSK39	Neural tissues, natural killer cells, T-cell subsets, small cell lung carcinoma.	Homophilic and heterophilic adhesion. Associated with activation or cytotoxicity in immune cells.
CD57 ⁸⁰	Human natural killer 1, HNK1, LEU7	Natural killer cell subsets⁸¹, T-cell subsets and monocytes.	Adhesion. Defines terminally differentiated senescent cells.
CD58 ⁸²	LFA3	Hematopoietic and non-hematopoietic cells.	APC-T-cell adhesion. Killer target cell interaction. Costimulation of CD58+ and CD2+ T-cells leading to adhesion and activation.
CD59 ⁸³	Protectin, MAC-inhibitory protein, MSK21	Hematopoietic and non-hematopoietic cells (widely expressed).	Prevents complement polymerization. Protects cells from complement mediated lysis.
CD60a	CDw60, GD3	Subsets of CD4+ and CD8+ peripheral T-cells, platelets, monocytes, melanocytes, adrenal medullary cells, glial cells, neurons, thymocytes, peripheral T-cell subsets, B-cells and granulocytes.	The CD60 family are oligosaccharides present on gangliosides and are involved in co-stimulation of T-cells. Intracellular regulator of apoptosis in T cells.
CD60b	UM4D4, 9-O-acetyl-GD3	Subsets of CD4+ and CD8+ peripheral T-cells, platelets, monocytes, T-cell subsets, activated B-cells and neuroectodermal cells.⁸⁴	The CD60 family are oligosaccharides present on gangliosides and are involved in the co-stimulation of T-cells.⁸⁵ Involved in growth cone advancement from dorsal root ganglia.
CD60c	7-O-acetyl-GD3	Subsets of CD4+ and CD8+ peripheral T-cells, platelets, monocytes and T-cells.	The CD60 family are oligosaccharides present on gangliosides and are involved in co-stimulation of T-cells.
CD61 ⁸⁷	Integrin beta-3, ITGB3, GP3A	With CD41 on platelets, with CD51 on macrophages, endothelial cells, fibroblasts, megakaryocytes, osteoclasts, mast cells and macrophages.	Regulates extracellular signals and intracellular pathways. Plays a key role in embryonic development and sperm maturation.⁸⁶
CD62E	E-selectin, SELE, ELAM1, LECAM2	Activated brain endothelial cells.⁸⁸	Leukocyte rolling and adhesion to activated endothelium at inflammatory sites. Tumor cell adhesion and angiogenesis.
CD62L	L-selectin, SELL, LAM1, LECAM1, LYAM1, Leu-8	B- and T-cell subsets, monocytes, granulocytes, natural killer cells, neutrophils⁸⁹ and thymocytes.	Leukocyte rolling and homing on activated endothelium.
CD62P	P-selectin, SELP, LECAM3, GRMP, PADGEM	Activated platelets, thymic endothelial cells and megakaryocytes.	Leukocyte tethering and rolling on the surface of activated endothelial cells.
CD63 ⁹⁰	LAMP-3, Granulophysin, MLA1, ME491	Activated platelets, monocytes, neutrophils, dendritic, intestinal and melanoma cells.	Involved in regulation of membrane protein trafficking, leukocyte recruitment and adhesion processes.
CD64 ⁹¹	IgG Fc receptor I, FCGR1A, IGFR1	Monocytes, macrophages, eosinophils and neutrophil granulocytes.	Binds to the Fc region of IgG with high affinity, expression induced by bacterial infection.
CD65s ⁸⁵	VIM2	Granulocytes and myeloid cells. Low expression on monocytes.	Adhesive carbohydrate. Marks turning point in myeloid cell differentiation.
CD66a	CEACAM1, Biliary glycoprotein 1, BGP	Mature granulocytes, epithelial cells, hematopoietic tissues, neutrophils, colon and liver.⁹²	Neutrophil activation.⁹³ Involved in signal transduction.
CD66b ⁹⁴	CEACAM8, CD67, CGM6, NCA-95	Granulocytes, eosinophils and neutrophils.⁹⁵	Cell adhesion. Superoxide production. Degranulation of eosinophils.⁹⁵ Neutrophil activation.⁹³
CD66c	CEACAM6, NCA, CEAL	Normal mucosal colon epithelia, lung granulocytes and epithelial cancers.⁹⁶	Cell adhesion and aggregation. Neutrophil activation.⁹³ Expression upregulated in certain cancers
CD66d	CEACAM3, CGM1	Neutrophils.	Cell adhesion and neutrophil activation.⁹³
CD66e⁹⁷	CEACAM5, CEA	Epithelial cells, endotheliocytes, hemocytes, platelets and immune cells.	Homophilic and heterophilic adhesion. May promote tumor development.
CD66f	Pregnancy-specific beta-1-glycoprotein 1, PSG1, PSBG1, B1G1, SP1	Eptihelial cells, placental syncytiotrophoblasts and fetal liver.⁹⁸	Immune regulation and protection of fetus from the maternal immune system.⁹⁸
CD67	See CD66b
CD68	SCARD1, KP1	Monocytes, macrophages, neutrophils, basophils, dendritic cells and myeloid progenitors.	Specific marker for tumor-associated macrophages (TAMs).⁹⁹ Positive cells infiltrate tumors which reflects severity. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Possible role in phagocytic activities of tissue macrophages. May allow macrophages to crawl over selectin-bearing substrates or other cells.
CD69	Activation inducer molecule, AIM, CLEC2C, EA1	Hematopoietic stem cells, T-cells, natural killer cells and other immune cells.	Early activation marker, implicated in the differentiation of T-cells and NKT2s¹⁰⁰ as well as in lymphocyte retention in lymphoid organs.
CD70	CD27L, TNFSF7	Activated B- and T-cells, dendritic cells and macrophages.	Ligand for CD27 which promotes effector CD8+ T-cell responses. Promotes tumor proliferation/migration. Creates an immunosuppressive tumor microenvironment.¹⁰¹
CD71	Transferrin receptor protein 1, TFRC	Erythroid cells and endothelial cells of BBB.	Controls iron uptake during cell proliferation.¹⁰²
CD72	LYB2	B-cells (but not plasma B-cells), macrophages, follicular dendritic cells, epithelial cells and endothelial cells.	Co-receptor of BCR. Involved in B-cell proliferation, apoptosis and differentiation.¹⁰³
CD73 ¹⁰⁴	5'-nucleotidase, NT5E, E5NT	Mesenchymal stem cells, cancer stem cells, follicular dendritic cells, endothelial cells and variable proportions of adaptive immune cells.	Nucleotidase. Plays role in adhesion for cell: cell and cell: matrix interactions.
CD74	DHLAG, Ia-GAMMA, HLADG	B-cells, activated T-cells, monocytes, macrophages, Langerhans cells, dendritic cells, stromal cells, endothelial cells, and epithelial cells. Also expressed in hematologic malignancies.¹⁰⁵	Intracellular sorting of MHC class II molecules. Plays a diverse role in immune responses.
CD75	ST6GAL1, Sialyltransferase 1, CDw75	Mature and activated B-cells¹⁰⁶ and T-cell subsets and erythrocytes.¹⁰⁷	Catalyzes the transfer of sialic acid from CMP sialic acid to galactose-containing substrates. Cell adhesion.
CD75s	-	B- and T-cell subsets.	CD75s differentiation antigens are cell-surface carbohydrate determinants generated by CD75.
CD77 ¹⁰⁸	Globotriaosylceramide , BLA, Gb3	Germinal center B-cells and macrophages. High expression in Burkitt’s lymphocytes.	Induces apoptosis of B-cells. Receptor for E. coli verotoxin.
CD79a	MB1, IGA	B-cells and immature bone marrow myeloid cells.	Subunit of B-cell antigen receptor (CD79a+CD79b). Plays role in tumor-promoting effects of myeloid cells.¹⁰⁹
CD79b	B29, IGB	B-cell malignancies, pre-B cells and mature B-cells (excluding plasma cells).¹¹⁰	Subunit of B-cell antigen receptor (CD79a+CD79b). Plays a critical role in B-cell maturation and activation.
CD80	B7-1	Activated B- and T-cells, macrophages and dendritic cells.¹¹¹	Co-stimulation of T-cell activation and proliferation. Plays a role in B-cell activity. Has a critical role in autoimmune, humoral, and transplant responses.
CD81	TAPA1, Tetraspanin-28, S5.7	B- and T-cells, natural killer cells, monocytes, thymocytes, dendritic cells, endothelial cells and epithelial cells.	Mediates signal transduction involving regulation of cell development, activation, growth and motility.¹¹² Facilitates complement recognition.
CD82	KAI1, Tetraspanin-27, 4F9, C33, GR15, SAR2, ST6	Leukocytes (upregulated on activation) and platelets.	Metastasis suppressor. Expression is downregulated in tumor progression.¹¹³
CD83	HB15, BL11	Activated B- and T-cells, regulatory T cells, circulating dendritic cells and Langerhans cells.¹¹⁴	Regulates antigen presentation and dendritic cell-dependent allogeneic T-cell proliferation.¹¹⁴
CD84	LY9B, SLAMF5	Mature B-cells, T-cell subsets, monocytes, macrophages¹¹⁵, platelets, and granulocytes.	Homophilic adhesion molecule. Enhances T-cell and NK cell activation and cytokine production.
CD85a	LILRB3, ILT5, LIR3, HL9	Monocytes, macrophages, myeloid cells, some T-cells, natural killer cells, neutrophils, basophils, eosinophils and B-cells.¹¹⁶	Inhibitory receptor for MHC class I molecules. Inhibits stimulation of immune response and limits autoreactivity.
CD85b	LILRA6, ILT8	Monocytes, macrophages, T-cell and natural killer cell subsets, dendritic cells and B-cells.	Involved in natural killer cell mediated cytotoxicity.
CD85c	LILRB5, LIR8	Natural killer cells, lymphocytes, mast cells, monocytes, macrophages and osteoclasts.	Involved in negative regulation of immune cell activation. May act as receptor for class I MHC antigens.¹¹⁷
CD85d	LILRB2, ILT4, LIR2, MIR10	Monocytes, macrophages, B- and T-cells, dendritic cells, eosinophils and natural killer cells.¹¹⁸	Receptor for class I MHC antigens. Downregulates the immune response and is involved in the development of tolerance.
CD85e	LILRA3, ILT6, LIR4	B-cells, natural killer cells, peripheral blood monocytes and lung.	May act as a soluble receptor for class I MHC antigens.
CD85f	LILRB7, ILT11, LIR9, LILRA5	Hematopoitic cells, natural killer cells, monocytes, B- and T-cells.¹¹⁹	May have a role in triggering innate immune responses.
CD85g	LILRA4, ILT7	Eosinophils, neutrophils, plasmacytoid dendritic cells and monocytes.	May act as a receptor for class I MHC antigens.¹²⁰
CD85h	LILRA2, ILT1, LIR7	Monocytes, B-cells, NK and dendritic cells.¹²¹	Activated receptor inhibits dendritic cell differentiation, antigen presentation and suppresses innate immune response.
CD85i ¹²²	LILRA1, LIR6	B-cells.	Contributes to the regulation of immune responses.
CD85j	LILRB1, ILT2, LIR1, MIR7	B-cells, monocytes, dendritic cells, subsets of natural killer and T-cells.	Involved in checkpoint inhibition, maintenance of T-cell homeostasis, and prevention of memory inflation with aging and CMV infection.¹²³
CD85k	LILRB4, ILT3, LIR5, HM18	Monocytes, macrophages, and dendritic cells.	Mediator of immune tolerance.
CD86	CD28LG2, B7-2, LAB72	Monocytes, APCs, endothelial cells, activated B- and T-cells.	Costimulation of T-cell activation and proliferation. Along with CD80, is a ligand of CD28 for optimal T-cell activation, which initiates immune reactions.¹²⁴
CD87	UPAR, PLAUR	Granulocytes, monocytes, natural killer cells, T-cells, endothelial cells, fibroblasts and hepatocytes. Highly expressed on senescent cells, malignant tumors, CAFs.¹²⁵	Influences normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the ECM.
CD88	C5R1, C5AR	Granulocytes, monocytes, macrophages, neutrophils, astrocytes, microglia and neurons.¹²⁶	Modulates inflammatory responses, obesity development, and cancers. Receptor for C5a.¹²⁶
CD89	FCAR	Monocytes, macrophages, eosinophils, and neutrophils.¹²⁷	IgA Fc receptor (binds IgA and eliminates IgA coated targets). Induces phagocytosis, degranulation, respiratory burst, and killing of micro-organisms.¹²⁷
CD90	THY1	Mesenchymal stem cells¹²⁸, hematopoietic cells, neuronal cells, fibroblasts, stromal cells and activated endothelial cells.	Involved in cell proliferation, cell: cell adhesion and cell migration.
CD91	LRP1, A2MR, APOER	APCs.¹²⁹	Critical for efficient immune-surveillance of tumors, activating natural killer cell responses, and priming T-cells.¹²⁹
CD92	CTL1, SLC44A1, CHTL1	BMSCs, with increased expression when differentiated towards osteogenic and adipogenic lineages.¹³⁰	Choline transporter. May be involved in membrane synthesis and myelin production.
CD93	C1qR, C1QR1, MXRA4	Endothelial cells¹³¹ and neutrophils.	Required for tubular morphogenesis, migration, and adhesion of endothelial cell. Organizes the endothelial cytoskeleton and cell junctions.¹³¹
CD94	KLRD1, NKG2	Natural killer cells and T-cell subsets.	Inhibition of natural killer cell function. Induces cytolytic activity and cytokine production.¹³²
CD95	Apoptosis antigen ligand, FASLG, APTL, TNFSF6, APO-1	Ubiquitously expressed in body, but abundant in thymus, liver, heart and kidney.¹³³	Induces apoptosis.¹³³
CD96	Tactile	Low levels on peripheral T-cells. Strongly up-regulated after T-cell activation.	Co-expressed with PD-1, TIGIT, and other checkpoints to regulate lymphocyte activity and anti-tumor immunity.¹³⁴
CD97	TM7LN1	Lymphocytes, monocytes, macrophages, dendritic cells, granulocytes, smooth muscle.	Involved in cell adhesion, migration and regulation of intercellular junctions.¹³⁵
CD98	4F2hc, SLC3A2, MDU1, NACAE	Monocytes, lymphocytes natural killer cells and granulocytes.	Cell surface glycoprotein essential for membrane localization of its transporter (LAT1) to provide amino acids to cells.¹³⁶
CD99	MIC2	Lymphocytes, natural killer cells, monocytes, granulocytes, endothelial cells, epithelial cells, some tumor cells and thymocytes.¹³⁷	Involved in apoptosis, adhesion, differentiation and protein trafficking.¹³⁷
CD100	Semaphorin 4D, SEMA4D, M-sema G	Hematopoietic cells, with higher expression on T-cells. ¹³⁸	Involved in T-cell priming, antibody production, and cell: cell adhesion.¹³⁸
CD101	IGSF2, EWI101	Myeloid and lymphoid subsets.¹³⁹	Inhibits T-cell activation and proliferation. Inhibits IL2RA expression on activated T-cells.
CD102 ¹⁴⁰	ICAM2	Resting lymphocytes, monocytes, platelets and vascular endothelial cells.	Binds to LFA-1, plays a major role in spermatogenesis and possibly lymphocyte recirculation. Mediates adhesive interactions.
CD103	Integrin alpha E, ITGAE	Intra-epithelial lymphocytes, some peripheral blood lymphocytes, activated lymphocytes, and subsets of dendritic cells in the gut.	Lymphocyte retention. Receptor for E-cadherin. Regulates lung inflammatory responses.¹⁴¹
CD104 ¹⁴²	Integrin beta 4, ITGB4	Basal layer of cells.	Adhesion receptor (for laminins) in normal epithelia, associates with alpha 6 subunit. Has a role in migration and tumor metastasis, alongside proliferation, survival, and wound healing.
CD105	Endoglin, ENG, END, ORW	Endothelial cells, mesenchymal stem cells, erythroid precursors, activated monocytes and macrophages.	Angiogenesis. Regulatory component of TGF-beta receptor complex. Modulates cellular response to TGF beta 1.¹⁴³
CD106	VCAM1, L1CAM	Activated endothelial cells.	Leukocyte adhesion. Transmigration and costimulation of T-cells.¹⁴⁴
CD107a	LAMP1	Activated platelets, activated T-cells, activated NK cells, activated endothelial cells and activated granulocytes.	Marker for cell-mediated lysis of target cells. Plays a role in the survival of NK cells against degranulation.¹⁴⁵
CD107b	LAMP2	Activated platelets, activated T-cells and activated endothelial cells.	Critical for lysozyme function. May be involved in leucocyte adhesion.¹⁴⁶
CD108	Semaphorin 7A, SEMA7A, SEMA-K1, SEMAL	Activated lymphocytes, erythrocytes and multiple adult tissues.	Ligand for Plexin C1. Plays important role in immunoregulation of the brain.¹⁴⁷
CD109	FLJ38569	Activated T-cells, activated platelets, subset of CD34+ cells and endothelial cells.	May play a critical role in tumor progression.¹⁴⁸
CD110	TPOR, MPL	Subset of stem cells and cells of megakaryocytic lineage, as well as platelets.¹⁴⁹	Binds to thrombopoietin induces megakaryocyte proliferation and differentiation and prevents apoptosis.
CD111	Nectin1, PVRL1, HVEC	Widely expressed in cell lines of different lineages, including neuronal cells.¹⁵⁰	Entry mediator for several herpesvirus (HSV1, HSV2, PRV, BHV1)¹⁵⁰. Believed to be involved in cell adhesion mechanisms.
CD112	Nectin2, PVRL2, HVEB	Broadly expressed on normal epithelial, neuronal and fibroblastin cells, with elevated expression on tumor cell lines.¹⁵¹	Ligand for CD226,¹⁵²upon interaction, becomes a negative regulator of NK cell effector function.¹⁵¹
CD113	Nectin3, PVRL3	T-cells.¹⁵²	Adhesion molecule that interacts with afadin which connects nectin to the actin cytoskeleton.
CD114	GCSFR, CSF3R	Blood vessels of cardiac ventricles, intestine, kidney glomerulae and CNS. Endothelial cells in embryo, muscles, and their progenitors. Neurons.¹⁵³	Involved in early development of nervous system and radial glial cell function.¹⁵³
CD115	CSF1R, FMS	Monocytes, macrophages, monocytic progenitors, neuronal cells and osteoclasts.	Receptor for M-CSF which is necessary for skeletal growth, cytoskeletal organization and osteopetrosis.¹⁵⁴
CD116	GM-CSF-R-alpha, GMCSFR, CSF2RA	Monocytes, macrophages, neutrophils, fibroblasts, myeloid dendritic cells, endothelial cells, placental trophoblasts and eosinophils.	Myeloid cell hematopoiesis and production of WBCs.
CD117	c-kit, KIT, SCFR	Hematopoietic and lymphoid cell types, such as dendritic cells, NK cells and mast cells.¹⁵⁵	Receptor tyrosine kinase which phosphorylates multiple intracellular proteins that play a role in proliferation, differentiation, migration, and apoptosis.¹⁵⁵
CD118	LIFR, SWS, STWS	Epithelium cells.	Tumor suppressor in breast cancer.¹⁵⁶ Affects the differentiation, survival and proliferation of a wide variety of cells.
CD119	IFNGR1	Lymphocytes, natural killer cells, monocytes, macrophages, granulocytes, endothelial cells and epithelial cells.	Receptor for interferon-gamma.¹⁵⁷Role in host defense and immunopathological processes.
CD120a	TNF Receptor I, TNFRSF1A, FPF	Low-level constitutive expression on nearly all nucleated cells.	Receptor for TNF.¹⁵⁸ Activates the caspase family, which induces cell death.
CD120b	TNF Receptor II, TNFRSF1B	Induced expression on myeloid cells, peripheral T-cells, alveolar lymphocytes and macrophages	Receptor for TNF¹⁵⁸, which leads to NF-kB transcription and induction of proliferation, differentiation, cytokine production, and apoptosis.
CD121a	IL-1R type I, IL1R1	Fibroblasts, lymphocytes, monocytes, macrophages, granulocytes, dendritic cells. epithelial cells, and neural cells.	Receptor for IL1A, IL1B and IL1RN. Mediates many cytokine-induced immune and inflammatory responses.¹⁵⁹
CD121b	IL-1R type II, IL1R2	B-cells, monocytes, macrophages, some T-cells and keratinocytes.	Non-signaling receptor for IL1A, IL1B and IL1RN. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1.¹⁶⁰
CD122	IL2RB, P70-75	Constitutive expression on CD4+ Tregs, induced upon activation of CD4, CD8 T-cells, B-cells and some myeloid-derived subsets.	IL2 and IL15 receptor beta chain signaling. With CD25 and CD132, compose trimeric receptor complex for IL-2 and involved in cell survival and proliferation.¹⁶¹
CD123	IL3RA	Low expression on normal hematopoietic stem cells, neural progenitors and neurons¹⁶² with high expression in leukemic cells.	Receptor for IL3. Associates with the GM-CSF receptor. Involved in normal cell development.
CD124 ¹⁶³	IL4RA, IL4R	Endothelial cells, epithelial cells, fibroblasts, mature B- and T-cells. Low expression on leukocytes and progenitors.	Receptor for IL4 and IL13, which are involved in regulating IgE production.
CD125	IL5RA, IL5R	Eosinophils, basophils, neutrophils¹⁶⁴, activated B-cells and mast cells.	Receptor for IL5.¹⁶⁴ Involved in suppression of ROS formation. Promotes growth and differentiation of eosinophil precursors. Activates mature eosinophils.
CD126	IL6R, gp80	Activated B- and plasma cells, T-cells, monocytes, epithelial cells and fibroblasts.	Along with CD130, is a receptor for IL6 and plays a central role in myeloma cell proliferation and survival.¹⁶⁵
CD127	IL7R	Naive and memory CD4 and CD8 T-cells.¹⁶⁶	Receptor for IL7. Involved with T-cell homeostasis and function.¹⁶⁶
CD128a	See CD181
CD128b	See CD182
CD129	IL9R	Hematopoietic cells including T-cells, neutrophils, mast cells and macrophages.¹⁶⁷	Receptor for IL9. Supports erythroid colony formation and synergizes with IL4 in the production of IgE and IgG.
CD130	IL6ST, gp130	T-cells, activated B-cells, plasma cells, monocytes and endothelial cells.¹⁶⁸	Transmits activities of IL6, IL11, LIF and CNF. Important in signal transduction.¹⁶⁸
CD131	IL3RB, IL5RB, CSF2RB	Monocytes, neutrophils, eosinophils, fibroblasts, endothelial cells and hematopoietic stem cells.	Component of the high affinity IL3, GM-CSF and IL5 receptors. Crucial role in growth/activation of eosinophils and in the inflammatory response. Co-localizes with EPO-R and is observed to offer tissue-protective effects.¹⁶⁹
CD132	IL2RG, IMD4, SCIDX	Variety of leukocytes including B- and T-cells, natural killer cells, monocytes, macrophages and neutrophils.¹⁷⁰	Forms complexes with other cell surface proteins including CD25, CD122, CD124, CD127 and others. Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the CD132 containing complexes, these cytokines regulate lymphocyte development and activation.
CD133	Prominin-1, PROM1, AC133	Hematopoietic stem cell subsets, epithelial, endothelial and neural cell precursors.	Binds cholesterol in cholesterol-containing plasma membrane microdomains. Involved in regulation of MAPK and Akt signaling pathways. Associated with cell development, ion homeostasis and cell communication.¹⁷¹
CD134	TNFRSF4, ACT35, OX40	Activated T-cells, NK cells, NKT cells and neutrophils.¹⁷²	Acts as a co-stimulatory receptor to NF-kB.
CD135	FLT3, FLK2, STK1	Bone marrow cells during early stages of hematopoiesis.	Binds FLT3 ligand to promote the growth and differentiation of progenitor cells. Required for dendritic cell homeostasis.¹⁷³
CD136	RON, PTK8, MST1R	Epithelial cells of skin, kidney, lung, liver, intestine, colon and on certain hematopoietic cells, neuroendocrine cells and keratinocytes. Expression on monocytes, granulocytes and resident macrophages.¹⁷⁴	Receptor for macrophage-stimulating protein (MSP) which regulates cell adhesion, motility, growth, and survival. Implicated in the progression of several epithelial cancers.¹⁷⁴
CD137	TNFRSF9, ILA, 4-1BB	Activated T-cells.¹⁷⁵	Costimulation of T-cell activation. Regulates T-cell-dependent immune responses. Involved in the development and activation of immune cells.¹⁷⁵
CD138	Syndecan, SDC1, SYND1	Epithelial cells.¹⁷⁶	Modulates processes relevant to tumor progression. Co-receptor for growth factors, angiogenic factors, morphogens and chemokines.¹⁷⁶
CD139	-	B lymphocytes, monocytes, granulocytes, weakly expressed on erythrocytes.	Unknown.
CD140a	PDGFR-alpha, PDGFRA	Fibroblasts, mesenchymal cells¹⁷⁷, platelets, OPCs and chondrocytes.	Cell proliferation, differentiation, and survival.
CD140b	PDGFR-beta, PDGFRB, JTK12	Adipose-derived stem cells¹⁷⁸, fibroblasts, mesenchymal cells, platelets, glial cells and chondrocytes.	Cell proliferation, differentiation and survival. Enhances the angiogenic potential of endothelial cells.
CD141	Thrombomodulin, THBD, THRM, BDCA-3	Monocytes, neutrophils, platelets, endothelial cells, keratinocytes, and minor subpopulation of myeloid dendritic cells.¹⁷⁹	Co-factor in activation of protein C and initiation of protein C anticoagulant pathway.
CD142	Tissue factor, F3	Vascular cells: smooth muscle, pericytes and adventitial fibroblasts.	Initiates blood clotting. Key regulator of homeostasis.¹⁸⁰
CD143	Angiotensin Converting Enzyme 1 (ACE), DCP1	Endothelial cells, epithelial cells, dendritic cells, neuronal cells, adult mesenchymal stem cells¹⁸¹ and activated macrophages.	Converts angiotensin I to angiotensin II by the release of terminal His-Leu, which results in an increase of the vasoconstrictor activity of angiotensin.
CD144	VE-cadherin, Cadherin-5, CDH5, 7B4	Endothelial cells and stem cell subsets.¹⁸²	Cell adhesion, mediates cell: cell contact between endothelial cells.¹⁸²
CD146	MCAM, MUC18	Endothelial cells, follicular dendritic cells, activated T-cells and smooth muscle.	Involved with bone formation, trans-endothelial migration and homing to injured bone sites.¹⁸³
CD147	Basigin, BSG, 5F7, EMMPRIN, M6, OK, TCSF	Epithelial, neuronal, lymphoid and myeloid cell types.	Cell adhesion and T-cell activation. Involved in MMP function, regulation of cytoskeletal remodeling, cell recognition during neuronal-glial patterning and aggregation.¹⁸⁴
CD148 ¹⁸⁵	DEP1, PTPRJ, SCC1	Monocytes and macrophages.	Tyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle, and oncogenic transformation. May regulate signal transduction, suppresses phosphorylating activity and accelerates the degradation of EGFR.
CD150	SLAM, SLAMF1, IPO-3	T-cells (upregulated on activation), regulatory T-cells, B-cells, dendritic cells, macrophages and activated monocytes.¹⁸⁶	Costimulation of T-cells and B-cells, major entry receptor for measles.¹⁸⁶
CD151	GP27, SFA-1, PETA-3	T-cell subpopulations, endothelial cells and epithelial cells.	Marker of aggressive cell proliferation and invasiveness for a variety of cancers.¹⁸⁷ Associates with laminin-binding integrins. Regulates cell motility via proteases.
CD152	CTLA-4	Activated T-cells.¹⁸⁸	Negative regulation of T-cell activation. Contributes to the maintenance of peripheral T-cell tolerance to self antigens. It exerts its major effects on T-cell immune responses via regulation of the cell cycle.
CD153	CD30 ligand, TNFSF8	B-cells.	Binds to CD30 and induces proliferation of T-cells.¹⁸⁹
CD154	CD40 ligand, Gp39, TRAP, HIGM1	Activated CD4+ T-cells and activated platelets.¹⁹⁰	Mediates B-cell proliferation and IgE production in the presence of IL4. Also involved in antibody class switching, modulation of apoptosis in the germinal center through interaction with B-cells expressing CD40 and activation of CD4+ T-cells.¹⁹⁰
CD155	Poliovirus Receptor, NECL-5, TAGE4	Broadly distributed in variety of normal cells and tissues, with high expression in malignant tumors.¹⁹¹	Mediates natural killer cell adhesion and triggers their effector functions. Plays a role in mediating tumor cell invasion and migration.¹⁹¹ Receptor for poliovirus attachment.
CD156a	ADAM8, MS2	Monocytes, granulocytes and B-cells, also found on neurons, reactive glia cells and oligodendrocytes	Plays important role in bone morphogenesis and is involved in the allergic inflammatory process.¹⁹²
CD156b	ADAM17, TACE, cSVP	Ubiquitously expressed – brain, heart, kidney, skeletal muscle.¹⁹³	Cleaves transmembrane form of TNF-α to generate the soluble active form.¹⁹³
CD156c	ADAM10, MADM, HsT18717	Spleen, lymph nodes, thymus, peripheral blood leukocytes, bone marrow, chondrocytes, neurons and fetal liver.	Mediates the ectodomain shedding of several transmembrane proteins.¹⁹⁴ Cleaves the amyloid precursor protein, which prevents the formation of amyloid peptide AB.
CD157	BST-1	Low levels found on neutrophils, myeloid suppressor cells and mesothelioma cells, bone marrow stromal cells, macrophages, monocytes, vascular endothelium and circulated endothelial cells.¹⁹⁵	Involved in immunity, cancer and metabolism through cell adhesion/migration.¹⁹⁵
CD158a	NKAT-1, KIR2DL1, CL-43, p58.1	Natural killer cells and T-cell subsets.	Receptor on natural killer cells for HLA-C alleles. Inhibits the activity of natural killer cells thus preventing cell lysis.¹⁹⁶
CD158b1	NKAT-6, KIR2DL2, CL-43, p58.2	Natural killer cells and T-cell subsets.	Receptor on natural killer cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of natural killer cells thus preventing cell lysis confers strong inhibition of HIV-1 replication.¹⁹⁷
CD158b2	NKAT-2, KIR2DL3, CL-6, p58	Natural killer cells and T-cell subsets.	Receptor on natural killer cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of natural killer cells thus preventing cell lysis.¹⁹⁸
CD158c	KIR3DP1, KIR2DS6, KIRX	Natural killer cells.	Secreted to the extracellular medium and involved in the suppression of natural killer cell-mediated cytotoxicity.¹⁹⁹
CD158d	KIR2DL4, KIR-103AS	Natural killer cells.	Receptor on natural killer cells and possesses both activating and inhibitory signaling domains.²⁰⁰
CD158e1	NKAT-3, KIR3DL1, AMB11, CL-2	Natural killer cells.	Receptor on natural killer cells for HLA Bw4 allele. Inhibits the activity of natural killer cells thus preventing cell lysis.
CD158e2	NKAT-1, KIR3DS1	Unknown.	Unknown.
CD158f	KIR2DL5, KIR2DL5.1, KIR2DL5.3	Natural killer cells, S100B= Schwann cells.²⁰¹	Regulates cell proliferation in an AKT/mTOR-dependent fashion.
CD158g	NKAT-9, KIR2DS5	Natural killer cells.	Receptor on natural killer cells for HLA-C alleles. Presence signals a decreased risk of endometriosis in women.²⁰²
CD158h	KIR2DS1, EB6ActI, p50.1	Natural killer cells.	Receptor on natural killer cells for HLA-C alleles. Recognizes ligand from HCMV infected cells.²⁰³
CD158i	NKAT-8, KIR2DS4, KKA3, PAX	Natural killer cells.	Receptor on natural killer cells for HLA-C alleles. Strong activator of NK cells and provides protection from preeclampsia and glioblastoma. Does not inhibit the activity of natural killer cells.²⁰⁴
CD158j	NKAT-5, KIR2DS2, 183ACTI, CL-49, p50.2	Natural killer cells.	Receptor on natural killer cells for HLA-C alleles. Stimulates NK cells for increased cytotoxic potential.²⁰⁵
CD158k	NKAT-4, KIR3DL2, CL-5	Natural killer cells and T-cells.	Receptor on natural killer cells for HLA-A and -B27 alleles, negatively regulates NK and T-cell effector function.²⁰⁶ Acts as a receptor on astrocytes and may protect neurons from astrocyte-induced toxicity
CD159a	NKG2A, KLRC1	Natural killer cells and CD8+ T-cells.^{207, 208}	Negative regulation of natural killer cell activation. Implicated in the recognition of the MHC class I HLA-E molecules by natural killer cells and some cytotoxic T-cells.²⁰⁷ Recruits phosphatases to downregulate signaling.²⁰⁸
CD159c	NKG2C, KLRC2	Natural killer cells and CD8+ T-cells.^{207, 208}	Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by natural killer cells and some cytotoxic T-cells. Recruits DAP12.²⁰⁸
CD160	BY55, NK28	Peripheral blood natural killer cells and CD8+ T-cells with cytolytic effector activity.	Receptor showing broad specificity for both classical and non-classical MHC class I molecules, which regulates cell activation and differentiation. May serve in inhibitory role in CD8+ T cell function.²⁰⁹
CD161	NKR-P1A, KLRB1	T-cells.²¹⁰	Inhibits natural killer cell mediated cytotoxicity. Induces immature thymocyte proliferation.
CD162	PSGL-1, SELPLG	Monocytes, granulocytes, most T- and B-cells and stem cells.	Binds E-, P- and L-selectins and mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Involved in restraining T-cell responses.²¹¹
CD163	M130	Monocytes and macrophages.²¹²	Clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, expressed on TAMs and strong indicator of poor prognosis.²¹²
CD164	MUC-24, MGC-24, endoyn	Isoform 1: prostate cancer tumors and osseous metastases. Isoform 2: Small and large bowel as well as lung and thyroid epithelia. Isoform 4: Hematopoietic progenitor cells and bone marrow stromal cells.²¹³	Regulates the proliferation, adhesion and migration of hematopoietic progenitor cells, may regulate muscle development. ²¹³
CD165	AD2, gp37	Lymphocyte subsets, monocytes, immature thymocytes, platelets and epithelial cells.	Important for adhesion of thymocytes to thymic epithelial cells.
CD166	ALCAM, MEMD	Activated T- and B-cells, monocytes, thymic epithelial cells and neurons. Overexpressed in epithelial tumors.²¹⁴	Mediates cell adhesion by binding to CD6. Involved in neurite extension and may play a role in the binding of T- and B-cells to activated leukocytes.
CD167a	DDR1, CAK, EDDR1, NTRK4, PTK3	Highest expression in epithelial cells in the brain, gastrointestinal tract, lung, placenta and kidney. Overexpressed in some tumors.²¹⁵	Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation.²¹⁵
CD167b	DDR2, TKT, NTRKR3, TYRO10	Osteocytes, osteoblastic cells and bone lining cells. . Also expressed in heart and lung and invasive human breast tumors.	Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development.
CD168	HMMR, RHAMM	Abnormally expressed in myeloma cells and in other neoplastic B lymphocytes.	Hyaluronan receptor involved in cell migration, adhesion and signaling. With CD44, forms complexes that activate MAP/ERK1,2 pathway. Involved in EMT during metastasis.²¹⁶
CD169	Sialoadhesin, Siglec-1, SN	Macrophages.²¹⁷	Resides at entry site of lymphoid tissues and are the first cell type to bind particulate antigens to filter and remove foreign particles.²¹⁷
CD170	SIGLEC5, OB-BP2	Neutrophils, monocytes and B-cells.²¹⁸	Adhesion molecule mediating sialic-acid dependent binding to cells. Inhibits the activation of monocytes, macrophages and neutrophils. ²¹⁸
CD171	NCAM-L1, L1CAM, CAML1, SPG1	T- and B-cell subsets, monocytes and neurons. Overexpression in ovarian, endometrial, colorectal and non-small cell lung carcinomas.²¹⁹	Adhesion molecule involved in axon growth, fasciculation, neural migration and neuronal differentiation. Also necessary for kidney morphogenesis as well as interactions between leukocytes and endothelial cells.²¹⁹
CD172a	SHPS-1, SIRPA, PTPNS1	Monocytes, granulocytes, dendritic cells, brain cells stem cells and various tissues.²²⁰	Involved in negative regulation of receptor tyrosine kinase-couples signaling processes, suppression of anchorage-independent cell growth, control of macrophage nucleation, and skeletal muscle differentiation. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. CD47 binding prevents the maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.²²⁰
CD172b	SIRPB1, SIRP-BETA-1	Monocytes, macrophages, granulocytes and dendritic cells.²²¹	Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also involved in enhanced osteoclast differentiation and bone resorption.²²¹
CD172g	SIRPG, SIRPB2	CD4+ and CD8+ T-cells and activated NK cells.	Immunoglobulin-like cell surface receptor that mediates cell-cell adhesion on binding with CD47. May be involved in T-cell responses.²²²
CD173	Blood group H type 2	Erythrocytes, stem cell subsets and platelets.	Precursor to the A- and B-blood group antigens. May be used to identify immature MSCs.²²³
CD174	Lewis Y, FUT3	Stem cell subsets, erythrocytes and epithelial cells.	Catalyzes the fucosylation reaction to produce the Lewis blood-group antigen.²²⁴ May be involved in the homing process of hematopoietic stem cells to the bone marrow.
CD175	Tn	Limited amount found on normal tissue, hematopoietic and epithelial cells, but greater expression on cancer cells and fetal tissue.²²⁵	Histo-blood group related carbohydrate antigen.²²⁵ May be involved with adhesion and interaction with immune cells.
CD175s	Sialyl Tn	Erythroblasts, endothelial cells and epithelial cells.	Binds CD22, Siglec-3-5 and 6. Implicated in the induction of metastasis and invasiveness of tumors. Inhibits NKC cytotoxicity. Overexpressed in several carcinomas and is associated with poor prognosis.²²⁵
CD176	Thomsen-Friedenreich antigen	Hematopoietic cells and epithelial cells.²²⁵	Acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. May protect against apoptosis induction.²²⁵
CD177	NB1 glycoprotein, HNA-2a	Subset of neutrophils.²²⁶	Associates with B2 integrins and PECAM-1 for involvement in neutrophil migration.²²⁶
CD178	Fas ligand, CD95 ligand, TNFSF6	CD4+ and CD8+ T lymphocytes, non-activated NK cells, parenchymal cells of retina and cornea, retinal pigment epithelial cells, neutrophils, autoimmune thymocytes and immature dendritic cells.	T-cell mediated cytotoxicity. Induces apoptosis in Fas-expressing target cells.²²⁷ Involved in regulation of immune response.
CD179a	VpreB1, IGVPB	Early stages of B cell development.²²⁸	Regulates Ig gene rearrangements in early steps of B-cell differentiation.²²⁸
CD179b	λ5, IGLL1	Early stages of B cell development.²²⁸	Involved in transduction of signals for cell proliferation, differentiation, allelic exclusion at the Ig heavy chain locus and promotion of Ig light chain gene rearrangements.²²⁸
CD180	RP105, LY64	Macrophages, dendritic cells and B-cells.	Mediates the innate immune response to bacterial LPS in B-cells. Tightly associated with the pathogenesis of autoimmune diseases.
CD181	CXCR1, IL8R alpha	Neutrophils.	Receptor for IL8, upon binding leads to neutrophil chemotaxis and activation.
CD182	CXCR2, IL8RB	Neutrophils.	Receptor for Il8 and CXCL1/MGSA. Mediates neutrophil migration to sites of inflammation.
CD183	CXCR3, GPR9, MigR	T-cell subsets, B-cells, natural killer cells, monocytes, macrophages and proliferating endothelial cells.	Receptor for CXCL9, CXCL10 and CXCL11. Upon ligand binding, induces responses that are involved in leukocyte traffic, integrin activation, cytoskeletal changes and chemotactic migration.
CD184	CXCR4, HM89, LESTR, WHIM	T-cell subsets, B-cells, dendritic cells, monocytes and endothelial cells.	Involved in AKT signaling cascade, regulates cell migration, hematopoietic progenitor cell homing and acts as co-receptor with CD4 for HIV-1 cell entry. Receptor for CXCL12.
CD185	CXCR5, BLR1, MDR15	Mature B-cells, T follicular helper cells and Burkitt lymphoma cells.	Binds B-cell chemoattractant BL. Involved in B-cell migration into B-cell follicles of spleen and Peyer patches.
CD186	CXCR6, BONZO, STRL33, TYMSTR	Th1 cells, natural killer T-cells and natural killer cell subsets.	Receptor for CXCL16. Involved in T-cell recruitment and is an HIV-1 co-receptor.
CD191	CCR1, CMKBR1, SCYAR1	Monocytes, neutrophils, lymphocytes and dendritic cells.	Receptor for MIP-1-alpha, MIP-1-delta, RANTES and MCP-3. Involved in leukocyte chemotaxis, host defense, hematopoiesis and T helper type 1/cell balance.
CD192	CCR2, CKR2, MCP-1-R	Monocytes, B-cells, activated T-cells and dendritic cells.	Receptor for monocyte chemoattractant protein-1 which mediates monocyte/macrophage chemotaxis and can be an HIV co-receptor.
CD193	CCR3, CKR3, CMKBR3	Eosinophils, basophils, Th1, Th2 cells, airway epithelial cells trace amounts in neutrophils and monocytes.	Receptor for several chemokines that may contribute to accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. Entry co-receptor for HIV-1.
CD194	CCR4, CKR4, HGCN	CD4+ T-cells, basophils, platelets, macrophages and natural killer cells.	Receptor for MIP-1, RANTES, TARC, and MCP-1 to regulate cell trafficking of leukocytes. Co-receptor for HIV-2.
CD195	CCR5, CCCKR5, CKR5, CMKBR5	Macrophages, natural killer cells and T-cell subsets.	May play role in control of granulocytic lineage proliferation or differentiation. HIV co-receptor.
CD196	CCR6, CKR-L3, GPRCY4	Immature dendritic cells , intestinal mucosal cells, naïve and memory T- and B-cells	Receptor for a C:C type chemokine, MIP-3-alpha/LARC. Affects dendritic cell chemotaxis. Important for B-lineage maturation and antigen-driven B-cell differentiation.
CD197	CCR7, BLR2, CMKBR7	Various lymphoid tissues, activated T- and B- cells. Strongly upregulated in B-cells infected with Epstein-Barr.	Activates B- and T- lymphocytes, controls migration of B-cells and memory T-cells to inflamed tissues, stimulates dendritic cell migration.
CD198	CCR8, CKR-L1, GPRCY6, TER1	Thymus.	Receptor for I-309, TARC and MIP-1-beta. Promotes recruitment of Th2 cells to sites of allergic inflammation. Co-receptor for HIV-1 infection.
CD199	CCR9, GPR28	T-cells that selectively migrate to the gastrointestinal tract.	Receptor for CCL25. May play a role in thymocyte recruitment and development, as well in inflammatory disorders of the gut. Alternate co-receptor for HIV-1 infection.
CD200	OX-2, MOX1	Endothelial cells and neurons.	Has a role in immunosuppression and regulation of anti-tumor activity.
CD201	EPCR, PROCR, CCCA	Endothelial cell subsets.	Receptor for activated protein C and involved in the protein C pathway controlling blood coagulation.
CD202b	TIE2, TEK, TIE2, VMCM	Endothelial cells and angioblasts.	Receptor for angiopoietin-1 and mediates steps involved with embryonic vascular development. Required for post-natal hematopoiesis, normal angiogenesis and heart development.
CD203c	ENPP3, B10, PDNP3	Basophils, mast cells and uterus.	Limits mast cell and basophil responses during inflammation, expression upregulated when these cells are activated by an allergy. Enzyme catalyzing hydrolysis of deoxynucleotides, nucleotide sugars and NAD.
CD204	MSR1, SCARA1, phSR2	Tumor-associated macrophages (TAMs).	Receptor implicated in macrophage-associated processes, such as adhesion, phagocytosis, production of ROS and host defense.
CD205	DEC205, LY75, CLEC13B	Dendritic cells, B-cells, macrophages and thymic epithelial cells.	Endocytic receptor enhancing antigen presentation, causes reduced proliferation of B-cells.
CD206	MMR, MRC1, CLEC13D	Macrophages, monocytes and dendritic cells.	Receptor that mediates endocytosis of glycoproteins by macrophages.
CD207	Langerin, CLEC4K	Langerhans cells.	Binds mannose which may lead to the internalization of antigen and provide access to nonclassical antigen-processing pathway.
CD208	LAMP3, DCLAMP, TSC403	Dendritic cells.	Dendritic cell maturation marker, involved in cell proliferation and adaptive immunity.
CD209	DC-SIGN	Dendritic cells, placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells and THP-1 monocytes.	Involved in initiation of the immune response, mediates antigen endocytosis and degradation binds pathogenic antigens such as HIV1 gp120.
CD210a	IL10RA, IL10R1	Monocytes, B- and T-cells and large granular lymphocytes.	Receptor for IL10, inhibits macrophage activation by interferon-gamma.
CD210b	IL10RB, IL10R2, CDw210B	Monocytes, macrophages, dendritic cells, B- and T-cells.	Co-expression with IL10RA is required for IL10-induced signal transduction. Forms part of the receptor complexes for IL10, IL22, IL26, IL28, and IL29.
CD212	IL12RB1, MGC34454	Activated T-cells and natural killer cells.	Forms part of the receptor complexes for IL12 and IL23.
CD213a1	IL13RA1, NR4	B- and T-cells, monocytes and endothelial cells.	Forms part of the receptor complexes for IL13 and IL4.
CD213a2	IL13RA2, IL13BP	B-cells and monocytes. High expression on certain tumors.	Binds IL13 with high affinity and may play role in the internalization of IL13.
CD215	IL15RA	Widely expressed in tissue and in circulation.	Receptor for IL15 and involved in osteoblast function.
CD217	IL17R, IL-17RA	Ubiquitous expression, mainly found on fibroblasts and endothelial cells.	Receptor for IL17A and IL17F, involved with immunosuppression.
CD218a	IL18R1, IL1RRP, IL-1Rrp	B- and T-cell subsets (Th1 cells), natural killer cells, monocytes, granulocytes and endothelial cells.	Forms part of the receptor complex for IL18 and plays a significant role in control of innate and adaptive immunity.
CD218b	IL18Rbeta, IL18RAP, ACPL	Natural killer cells, T-cell subsets, monocytes and endothelial cells.	Forms part of the receptor complex for IL18, plays important role in hypertension.
CD220	Insulin receptor, INSR	Widely expressed in tissue targets of insulin metabolic effects.	Tyrosine-protein kinase activity. Binding of insulin stimulates its association with downstream mediators including insulin receptor substrates and phosphatidylinositol 3'-kinase (PI3K), which leads to glucose uptake.
CD221	Insulin-like growth factor 1 receptor, IGF1R, JTK13	Wide tissue expression.	Involved in the growth and survival of normal and neoplastic cells.
CD222	M6PR, IGFII-R, MPRI, CIMPR	Lymphocytes, monocytes, granulocytes and fibroblasts, ubiquitously expressed.	Transports phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.
CD223	LAG-3	Effector memory T-cells. Upregulated on activated CD4+ and CD8+ T cells and subset of NK cells.	Immune checkpoint receptor that mediates a cell-intrinsic negative inhibitory signal.
CD224	GGT1	Lymphocytes as well as various tissues, eg kidney, liver, pancreas, stomach, intestine, placenta, lung.	Catalyzes the degradation of extracellular GSH to promote production of constituent amino acids, and helps maintain intracellular GSH.
CD225	IFITM1, Leu-13, Sep-27	Bone, with greatly elevated levels in colon, cervical, esophageal, and ovarian cancers. Also found in glioma cell lines.	Inhibits viral entry, implicated in cell adhesion, control of cell growth and migration.
CD226	DNAM-1, PTA1	Majority of immune cells, including T-cells and natural killer cells.	Important activating receptor, when engaged with ligand, activates NK cells.
CD227	MUC1, PUM, EMA	T-cells, monocytes, macrophages, epithelial cells and stem cell subsets.	Cell adhesion and signaling through phosphorylations and protein-protein interactions.
CD228	Melanotransferrin, MFI2, MAP97	Brain capillary endothelial cells, stem cells and melanoma cells. Soluble version found in serum.	Involved in cellular iron uptake. May be a biomarker for Alzheimer's disease.
CD229	Ly9, SLAMF3	T- and B-cells. High expression on NKT cells and marginal zone B-cells.	Involved in adhesion between T-cells and accessory cells. Acts as signaling inhibitory receptor, involved in maintenance of immune cell tolerance.
CD230	PrP, PRNP, ASCR	Abundantly expressed in neuronal cells.	Involved in complexes that modulate neuroprotection. Altered forms of the protein are responsible for prion diseases.
CD231	Tspan-7, TALLA-1, A15, TM4SF2b	T-cells and endothelial cells. Over expressed in certain cancers.	Plays important role in intercellular adhesion, invasion and metastasis.
CD232	Plexin-C1, VESP-R	Melanocytes, monocytes, B-cells and natural killer cells.	Receptor for SEMA7A, smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Potential anti-tumor role in melanomas.
CD233	BND3, AE1, SLC4A1	Erythrocytes and kidney cells.	Functions as an electro-neutral chloride/bicarbonate exchanger.
CD234	Duffy antigen receptor, DARC, CCBP1, GPD	Erythrocytes, macrophages, endothelial cells and epithelial cells.	Receptor for Plasmodium spp. Non-specific chemokine receptor.
CD235a	Glycophorin-A, GYPA, MNS	Erythrocytes.	Carries blood group antigens, major erythrocyte intrinsic membrane protein. Minimizes erythrocyte aggregation. A receptor for influenza virus, Plasmodium falciparum and Hepatitis A virus.
CD235b	Glycophorin-B (GYPB)	Erythrocytes.	Minor sialoglycoprotein in erythrocyte membranes, receptor for Plasmodium falciparum.
CD236	Glycophorin, GPC	Two isoforms produced by alternative splicing: Glucophorin-C is expressed in erythrocytes, Glycophorin-D is ubiquitously expressed.	Glycophorin-C regulates the stability of red cells.
CD238	Kell blood group glycoprotein, KEL	Erythrocytes, Sertoli cells and follicular dendritic cells.	Zinc endopeptidase cleaving endothelin 3 .
CD239	Lutheran blood group antigen, B-CAM	Erythrocytes, endothelial cells, epithelial cells and cancerous cells.	Receptor for laminin alpha-5, plays a role in cell adhesion to basement membranes.
CD240CE	Blood group Rh(CE) polypeptide, RH30A, Rh4	Erythrocytes.	Part of an oligomeric complex with a putative transport or channel function in the erythrocyte membrane.
CD240D	Blood group Rh(D) polypeptide, RHPII	Erythrocytes.
CD241	RHAG, RH50A	Erythrocytes.	Ammonium and carbon dioxide transporter, associated with rhesus blood group antigen expression.
CD242	ICAM-4, LW	Erythrocytes.	Ligand for the leukocyte adhesion protein LFA-1, critical in erythroblastic island formation.
CD243	MDR-1, ABCB1, ABC20	Apical cell membrane of epithelial and endothelial interfaces within the intestine, testis, kidney, liver, brain and placenta, stem cells and drug-resistant tumor cells.	Influences absorption, distribution, excretion and toxicology of exogenous substrates.
CD244	2B4, NAIL, SLAMF4	Natural killer cells, basophils, monocytes and leukemic cells.	Natural killer cell activation. Co-operates with c-Kit and p27 to activate SHP-2. Helps to maintain the stemness of leukemia initiating cells.
CD245	p220/240	Peripheral blood lymphocytes and NK lymphocytes.	Highly conserved motor enzyme, necessary for cytoskeleton organization and Golgi budding. Possible receptor for surfactant Protein A.
CD246	ALK	Embryonic neurons of CNS and PNS.	Enzyme which plays important role in brain development, also an oncogenic driver.
CD247	TCR Z chain, CD3H	T-cells and natural killer cells.	Part of the TCR complex. Essential for recognition of the antigenic peptide and immunosuppressive.
CD248	Endosialin, CD164L1	Stromal fibroblasts, pericytes, vascular smooth muscle cells, osteoblasts, upregulated in tumor growth environment.	Acts as microenvironmental sensor which mediates part of the adipose tissue response to hypoxia.
CD249	EAP, Aminopeptidase A, ENPEP	Epithelial cells and endothelial cells of many organs, predominant in kidneys.	Zinc metaloprotease that converts angiotensin II to angiotensin III.
CD252	OX40L, TNFSF4, GP34	Dendritic cells, activated B-cells, macrophages, NKT cells, endothelial cells and mast cells.	Member of TNF superfamily, implicated in the proliferation and survival of T-cells.
CD253	Apo-2L, TRAIL, TNFSF10	Activated T-cells and natural killer cells.	Initiates apoptosis of tumor cells by binding to either DR4 or DR5 receptors.
CD254	ODF, OPGK, RANKL, TRANCE, TNFSF11	Differentiated CD4+ T-cells and CD40-ligand stimulated mature DCs.	Enhances T-cell proliferation and T-cell: DC interactions. Crucial for the development of osteoclasts and lymph nodes.
CD256	APRIL, TALL-2, TRDL-1, TNFSF13	Leukocytes, pancreatic cells and colon.	Promotes AML cell growth by suppressing apoptosis and activating NF-kB.
CD257	BAFF, TALL-1, TNFSF13B, BLYS, ZTNF4	Mature B cells and plasma cells, monocytes, macrophages, T-cells and dendritic cells.	Involved in the stimulation of B- and T-cell function and is often elevated in autoimmune diseases.
CD258	TNFRSF14, HVEM-L, LIGHT	Activated T-cells and dendritic cells, activated monocytes and B-cells.	Interacts with LTbR to increase survival and proliferation of BM-MSCs.
CD261	DR4, TRAIL-R1, TNFRSF10A, Apor2	Activated T-cells, peripheral B-cells and selected tumor cells.	Induces apoptosis upon binding to TRAIL, inducing the formation of DiSC. Also activates non-apoptotic signaling pathways that result in proliferation.
CD262	DR5, TRAIL-R2, TNFRSF10B, TRICKB	Leukocytes and selected tumor cells.	Activated by TNFSF10 / TRAIL and transduces apoptosis signal.
CD263	DcR1, TRAIL-R3, TNFRSF10C, LIT, TRID	Low expression in most cells, high expression in tumor epithelial cells.	Receptor for TRAIL, competes with TRAIL-R1 and TRAIL-R2 thus inhibiting apoptosis.
CD264	DCR2, TRAIL-R4, TNFRSF10D, TRUNDD	Low expression in most cells and overexpressed in certain tumor cells.	Receptor for TRAIL, negatively regulates TRAIL-induced apoptosis and can influence the sensitivity of other cells in tumor microenvironment to TRAIL-induced apoptosis.
CD265	RANK, ODFR, TNFRSF11A, TRANCER	Heart, lung, brain, skeletal muscle, kidney, liver, skin and some cancers.	Mediates intracellular signaling, while overexpression in cancer cells results in abnormal proliferation and impaired differentiation, increasing the incidence of tumorigenesis.
CD266	TWEAKR, TNFRSF12A, FN14	Progenitor cells, with elevated expression in cancers, and endothelial cells.	Receptor for TWEAK. May contribute to endothelial dysfunction and may play a role in pathogenesis of autoimmune thyroid disease.
CD267	TACI, TNFRSF13B, CVID, TNFRSF14B	B-cells.	Receptor that plays an essential role during counterselection of early B-cells expressing self-reactive BCRs. Supports class-switch recombination, plasma cell differentiation and antibody secretion.
CD268	BAFF receptor, TNFRSF13C	Resting and mature B-cells.	B cell receptor for CD257. Regulates B-cell proliferation, survival, maturation and differentiation into plasma cells.
CD269	BCMA	Mature B-cells, normal plasma cells, high expression in multiple myeloma cells.	Receptor for CD256 and CD257, activates NFkB and JNK. Promotes B-cell survival and plays a role in the regulation of humoral immunity.
CD270	HveA, TR2, TNFRSF14, ATAR, HVEM	T follicular helper cells and antigen-presenting cells.	When bound to receptor BTLA (CD272), regulates inhibition and costimulation of several key players in the immune system. Plays an important role in Herpes simplex virus (HSV) pathogenesis.
CD271	NGF receptor, p75NTR	Widely expressed in central and peripheral nervous system. Overexpressed in many metastatic cancers.	Regulates neuronal growth, migration, differentiation and cell death. May promote tumor migration and invasion in metastatic cancers.
CD272	BTLA	CD4+ and CD8+ T-cells, macrophages, dendritic and NK cells.	Immune checkpoint that suppresses immune responses. Attenuates B-cell function.
CD273	PD-L2, B7-DC, PDCD1LG2	Dendritic cells and activated monocytes. Expression can be induced by inflammatory cytokines from immune and nonimmune cells.	Ligand for PD-1 and key regulatory immune checkpoint to maintain self-tolerance. Expression is associated with improved overall survival in some metastatic cancers.
CD274	PD-L1, B7-H1	Activated T- and B-cells, dendritic cells, keratinocytes, monocytes and tumor cells.	Ligand for PD-1 and key regulatory immune checkpoint to maintain self-tolerance. Essential for T-cell proliferation and production of interferon gamma and IL10.
CD275	B7-H2, B7RP-1, ICOSLG, LICOS	Activated monocytes, macrophages and dendritic cells.	Ligand for CD278. Costimulatory signal for T-cell proliferation and cytokine secretion. Expression associated with immune-mediated diseases
CD276	B7-H3	Limited expression in normal human tissues (prostate, breast, placenta, liver, colon and lymphoid organs) but overexpressed in the tumor microenvironment.	Immune checkpoint molecule that enhances the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
CD277	BTN3A1, BTF5	Subset of T-cells, natural killer cells, monocytes, dendritic cells and endothelial cells.	Involved in T-cell activation by phosphoantigens from malignant cells.
CD278	ICOS, AILIM	Activated T-cells.	Regulates maintenance of T follicular helper cells.
CD279	PD-1, PDCD1, SLEB2	Activated T- and B-cells. Upregulated in tumor tissue.	Inhibitory cell surface receptor and immune checkpoint inhibitor. High expression predictive of poor survival.
CD280	MRC2, UPARAP	Endothelial cells, fibroblasts and macrophages. Upregulated in a variety of cancers, and related to metastasis.	Endocytic receptor, closely involved with cancer metastasis. Acts in turnover of collagens within cell and in ECM.
CD281	TRL1, TIL	Plasmacytoid predendritic cells.	Pathogen recognition and activation of innate immunity. Regulates TLR2 function and responds to bacterial lipoproteins. Engages MAPK and NK-kB pathways.
CD282	TLR2, TIL4	Plasmacytoid predendritic cells.	Involved with IFN secretion. Activates the PI3K pathway. Involved in response to gram-positive bacteria.
CD283	TLR3	Alveolar macrophages.	Pathogen recognition molecule associated with viral infection from dsRNA.
CD284	TLR4, TOLL, hToll	Innate immune cells, neurons, astrocytes and microglia.	Involved in nervous system development. Regulates the differentiation and proliferation of adult neuronal precursor cells.
CD286	TLR6	Epithelial cells. High levels found in normal colon epithelium.	TLR6:TLR2 dimers coordinate macrophage activation by gram-positive bacteria and fungal zymosan. Initiates proinflammatory cascades and apoptotic responses.
CD288	TLR8	Monocytes, macrophages, dendritic cells and neurons.	Intracellular receptor that detects viral single-stranded RNA. Negative regulator of neurite outgrowth and induces neuronal apoptosis.
CD289	TLR9	Peripheral blood leukocytes, plasmacytoid pre-dendritic cells and lymphoma cells.	Binds unmethylated CpG DNA motifs found in microbial nucleic acids and activates the immune response.
CD290	TLR10	B-cells and dendritic cells, with high expression in lymphoma, AML and glioblastoma.	Immunomodulatory receptor with inhibitory properties.
CD292	BMPR-1A, ALK-3, ACVRLK3	Mesenchymal stem cells, various cells.	Receptor for BMP-2 and BMP-4. Plays a role in apoptosis and adipocyte development, cell differentiation and extracellular matrix deposition by osteoblasts.
CDw293	BMPR-1B, ALK6	Mesenchymal cells, bone progenitor cells, chondrocytes and epithelial cells.	Mediates TGF-b transduction. May act as a tumor suppressor in endometrial cancer.
CD294	GPR44, CRTH2	Th2 cells and eosinophils.	Involved in chemotaxis and eosinophil migration.
CD295	LEP-R, OB-R	Hematopoietic cells, heart, liver, kidney, neuron and pancreatic cells.	Receptor for leptin. Acts as an inflammatory cytokine, influencing the pathogenesis of multiple tumors.
CD296	ART1, RT6	Neutrophils, cardiac and skeletal muscle cells.	Required for methionine-induced ubiquitylation and endocytosis of the methionine transporter Mup1.
CD297	ART4, DOK1	Erythrocytes, monocytes, macrophages, basophils and endothelial cells.	Covalently modifies extracellular substrates by transferring a single ADP-ribose residue from NAD+ to a specific amino acid in the target protein. Antigen of Dombrock blood group system.
CD298	ATP1B3	Neuronal cells, generally expressed.	One of three regulatory B-subunits of Na+-K+ pump on neuronal membranes. Involved in HBV propagation.
CD299	CLEC4M, L-SIGN, DC-SIGNR	Liver and lymph node endothelial cells.	Pathogen-recognition receptor involved in peripheral immune surveillance in the liver. Involved in the adhesion, migration, invasion and metastasis of colon cancer cells.
CD300a	CMRF-35-H9, IRC1, IRp60, CLM8, MAIR	Myeloid cells (including macrophages, dendritic cells, granulocytes), bone-marrow-derived mast cells, B-cell subset, monocytes and natural killer cells.	Inhibitory receptor which inhibits IgE-mediated degranulation from mast cells.
CD300c	CMRF-35A, LIR	Monocytes and mast cells.	Activates mast cells and monocytes in an FcRg-dependent manner.
CD300d	CLM-4	Subsets of B-cells and peritoneal macrophages.	Stimulates pro-inflammatory cytokines and chemokine secretions from peritoneal macrophages.
CD300e	CLM-2, IREM-2	Monocytes, macrophages and myeloid dendritic cells.	Immune-activating receptor that provides cells with survival signals and triggers the expression of activation markers.
CD300f	CLM-1, IREM-1, LMIR3	Monocytes, macrophages, mast cells, microglia, oligodendrocytes and neurons.	Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Regulates clearance of apoptotic cells.
CD300g	CLM-9, TREM4	Endothelium.	May mediate L-selectin-dependent lymphocyte rolling.
CD301	CLEC10A, HML2	Macrophages, intermediate monocytes and tumor-associated macrophages (TAMs).	Involved in the regulation of adaptive and innate immune responses.
CD302	DCL-1, BIMLEC	Monocytes, macrophages, dendritic cells and granulocytes.	Functions in endocytosis and phagocytosis as well as in cell adhesion and migration.
CD303	CLEC4C, BCDA-2	Plasmacytoid dendritic cells.	Regulates the production of TLR-induced cytokines in PDCs.
CD304	Neuropilin 1, NRP1	Dendritic cells, T-cells, neurons and endothelial cells. Overexpressed in gastric cancer and cholangiocarcinoma.	Regulates VEGF-induced angiogenesis, dendritic cell and T-cell interaction, as well as EGF- and HGF-regulated signaling pathways.
CD305	LAIR1	T- and B-cells, natural killer cells, dendritic cells, monocytes, macrophages, eosinophils, mast cells and basophils.	Interacts with ligands to inhibit immune cell activation or differentiation.
CD306	LAIR2	T- and B- cells, natural killer cells, dendritic cells, monocytes, macrophages, eosinophils, mast cells and basophils.	Soluble receptor that binds collagen molecules and is natural competitor for LAIR-1.
CD307a	FcRL1, FCRH1, IFGP1, IRTA5	Mature B-cell subsets.	May function in B-cells activation and differentiation, acting as a positive regulator of B-cell activation.
CD307b	FcRL2, FCRH2, IRTA4	Memory B-cell subsets.	Inhibits activation when co-ligated with B-cell receptor.
CD307c	FcRL3, FCRH3, IRTA3, SPAP2	B-cells, subset of memory T-cells and natural killer cells.	Predicted to maintain homeostasis via regulation of immune responses.
CD307d	FcRL4, IRTA1, FCRH4	Memory B-cells.	Acts in cell cycle inhibition and induces B-cell exhaustion. Receptor for IgA.
CD307e	FcRL5, BXMAS1, FCRH5, IRTA2	Subset of memory B-cells.	Inhibitory receptor with expression associated with IgD downregulation and memory maturation.
CD309	VEGFR-2, KDR, FLK1	Endothelial cells and primitive stem cells.	Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation.
CD312	EMR2	Neutrophils.	Assist in neutrophil adhesion, migration and may enhance systemic inflammation.
CD314	NKG2D, KLRK1	Natural killer cells.	Mediates tissue stress surveillance and plays role in the control of tumors and infections.
CD315	PTGFRN, FPRP, SMAP-6, EWI-F	Megakaryocytes, hepatocytes, epithelial cells and endothelial cells.	Expression is essential for angiogenesis, and levels correlate with metastatic status of lung cancer.
CD316	IGSF8, EWI-2, KCT-4, PGRL	Brain, skin, olfactory sensory neurons and various tissues.	Negative regulator of cell motility and polarity. Critical regulator of CA3 microcircuit connectivity and function.
CD317	BST2, Tetherin	Bone marrow stromal cells and thymocytes.	Plays an essential role in innate immunity, defends against invading pathogens, such as viruses. Aberrant expression correlated with malignancies and poor prognosis.
CD318	CDCP1, SIMA135, gp140, Trask	Hematopoietic stem cells and epithelial cells. Overexpressed in a variety of human cancers.	Potent oncogene involved with cancer development, invasion and metastases
CD319	SLAMF7, CRACC, CS-1	Various immune cell types.	Ligates to EAT-2 expressing cells which results in activation of cellular immune responses. In absence of EAT-2, inhibits cellular responses by recruiting inhibitory phosphatases.
CD320	FDC-SM-8D6, TCbIR	Ubiquitous expression, including a subset of immune cells.	Receptor for vitamin B12 uptake.
CD321	JAM-A, JAM-1, PAM-1, F11R, KAT	Epithelial cells, endothelial cells and leukocytes.	Junctional adhesion molecule that regulates proliferation, migration and polarity in lymphocytes as well as endothelial cells. Influences epithelial tight junction formation.
CD322	JAM-B, JAM-2, VE-JAM	Heart, endothelium, trophoblasts of the placenta, high endothelial venules and arteriole endothelium.	Involved in regulation of endothelial and epithelial paracellular permeability, leukocyte recruitment during inflammation, angiogenesis, cell proliferation and migration.
CD324	E-Cadherin, CDH1	Epithelial cells, keratinocytes, trophoblasts and platelets.	Potent suppressor of invasion and metastasis. Plays a key role in determining cell polarity and differentiation. Necessary during the whole life cycle of an organism.
CD325	N-Cadherin, Cadherin-2, CDH2	Neurons, striated and cardiac muscle cells and mesenchymal cells.	Mediates transsynaptic adhesion, enables signaling through synapses. Mediates cell: cell adhesion.
CD326	Ep-CAM, EGP314, TACSTD1, TROP1, hEGP-2	Embryonic stem cells and suprabasal layers of normal mucosa. Strong expression in primary carcinomas.	Cell adhesion molecule and signaling protein that regulates cell proliferation and differentiation in cancer and stem cells. Plays a role in embryonic stem cells proliferation and differentiation.
CD327	Siglec-6, OB-BP1, CD33L	Mast cells, B-cells, basophils, and placenta trophoblastic cells.	Inhibitory receptor, which acts in the tumor microenvironment and modulates mast cell activity.
CD328	Siglec-7, AIRM-1, QA79	Eosinophils.	Downmodulates eosinophil activation but does not affect survival.
CD329	Siglec-9, SAF-2	Leukocytes.	Receptor that binds to hAOC3 and enhances its activity in recruiting leukocytes to sites of inflammation.
CD331	FGFR1, BFGFR, FLT-2	Ubiquitous expression.	Cell-surface receptor for fibroblast growth factors that have tyrosine kinase activity. Important for the normal formation of muscle and bone tissues.
CD332	FGFR2, KGFR	Primitive endoderm. Enhanced expression in the brain.	Cell-surface receptor for fibroblast growth factors. Plays an essential role in embryonic and postnatal development as well as in adult tissue maintenance.
CD333	FGFR3, ACH, JTK4	Skin, CNS and adult testes.	Cell-surface receptor for fibroblast growth factors. Plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Aberrant signaling of receptor is found in many cancers.
CD334	FGFR4, TKF, JTK2	Ubiquitously expressed.	Cell-surface receptor for fibroblast growth factors. Plays a role in the regulation of cell proliferation, survival and migration during embryonic development. Highly expressed in distinct cancer types.
CD335	NCR1, NK-p46, LY94	Natural killer cells.	Prototypal marker to define NK cells, is the cytotoxicity receptor that triggers the NK-target cell lysis when in contact with ligand.
CD336	NCR2, NK-p44, LY95	Activated natural killer cells.	Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer cells to mediate tumor cell lysis.
CD337	NCR3, NK-p30, LY117	Natural killer cells.	Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer cells to mediate lysis of tumor cells, virus-infected cells, fungal cells and dendritic cells.
CD338	ABCG2, MXR, BMDP, BCRP1	Mainly found in tissue interfaces (blood-brain barrier, placenta, liver, intestine).	Transporter protein involved in the absorption, distribution, metabolism and excretion of various drugs. Also involved in multidrug resistance in cancer cells.
CD339	Jagged1, JAG1, AHD, AWS	Widely expressed throughout mammalian development and across many tissues.	Ligand for multiple Notch receptors. Involved in the mediation of Notch signaling, cell fate determination in hematopoiesis and cardiovascular development.
CD340	ERBB2, MLN 19, NEU, HER2	Epithelial and endothelial cells, keratinocytes, hematopoietic stem cell subsets, fetal mesodermal cells and extraembryonic tissues.	Protein tyrosine kinase forming part of several cell surface receptor complexes. Essential component of a neuregulin-receptor complex, regulates outgrowth and stabilization of peripheral microtubules.
CD344	Frizzled-4 (Fz-4), FzE4, EVR1	Enteric nervous system, mature neurons and glial cells.	Receptor for Wnt proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis.
CD349	Frizzled-9, Fz-9, FZD9	Mesenchymal stem cells, neural precursors, mammary epithelial cells, neurons, testes and kidneys.	Receptor for Wnt protein, Wnt7a, and when bound leads to maintenance of normal lung epithelium.
CD350	Frizzled-10, Fz-10, FZD10	Adult brain, placenta, adult, fetal kidney, lung and brain.	Receptor for Wnt proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
CD351	FCAMR, FKSG87	Follicular dendritic cells in lymphoid organs and marginal zone B-cells.	Receptor for the Fc fragment of IgA and IgM. Suppresses T-independent antigen retention to downregulate germinal center formation and humoral immune responses.
CD352	NTB-A, SLAMF6, KALI, Ly108	Resting and activated T-cells, natural killer cells, B-cells and dendritic cells.	Acts as inhibitory checkpoint receptor on T-cells. When absent, established tumor cells are eradicated by CD8+ T-cells.
CD353	SLAMF8, BLAME, SBBI42	Macrophages and monocytes.	Negatively modulates Nox2 activity.
CD354	TREM-1	Monocytes, tissue macrophages, and neutrophils.	Engagement of receptor leads to activation of a cascade of intracellular events, resulting in the production of many chemokines, which amplifies inflammatory responses.
CD355	CRTAM	NK and T-cell subsets, splenocytes, thymocytes, peripheral blood leukocytes and Purkinje cells.	Involved in the early immune response to certain infections. A marker to identify NK cells.
CD357	TNFRSF18, AITR, GITR	T-cells (with increased expression upon cell activation), NK cells, lymphocytes, peripheral blood leukocytes and some myeloid populations.	Plays an important role in regulating immune responses by providing signals to boost T-cell activation.
CD358	TNFRSF21, Death receptor 6 (DR6)	Weak expression on resting peripheral CD4+ T-cells, but upregulated upon TCR stimulation; Tfh cells	Associated with regulation of T cell function in immunological diseases. May activate NF-kB and promote apoptosis.
CD360	IL-21R, IMD56	Lymphoid tissues, particularly thymus and spleen.	Receptor for interleukin-21, important for the proliferation and differentiation of T-, B-, and NK cells, as well as tumor progression.
CD361	EVI2B, D17S376, EVDB	B-cells, bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines. Expressed in most hematopoietic populations.	Involved in regulation of myeloid differentiation and HSPC function.
CD362	Syndecan-2, HSPG, SDC2, SYND2	T-cells, bone marrow- and umbilical cord-derived mesenchymal stromal cells.	Functions as integral membrane protein and mediates cell proliferation, cell migration and cell-matrix interactions.
CD363	S1PR1, D1S3362, edg-1	Endothelial cells, vascular smooth muscle cells, fibroblasts and melanocytes.	Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells and immune cell regulation
CD364	PI-16, dj90K10.5, MGC45378, CRISP9	Endothelial cells.	Inhibits cell migration when over-expressed.
CD365	HAVCR1, TIM-1	T cells, regulatory immune cells and APCs.	Receptor for hepatitis A virus and TiMD4. May be involved in the moderation of asthma and allergic diseases.
CD366	HAVCR2, TIM-3, TIMD3	CD4+ CD8+ T-cells, Th17 cells, regulatory T-cells and innate immune cells.	Immune checkpoint marker that mediates CD8+ T-cell exhaustion.
CD367	CLEC4, DCIR, DDB27, CLECSF6	Dendritic cells.	Involved in response to pathogens through support of type I IFN signaling to protect host tissue.
CD368	CLEC4D, MCL, CLECSF8, CLEC-6, MPCL	Monocytes subsets.	Activating C-Lectin Receptor, acts as receptor for mycobacteria.
CD369	Dectin-1, CLECSF12, CLEC7A	HSPCs.	Plays a main role in macrophage polarization.
CD370	HEEE9341, UNQ9341, DNGR1, CLEC9A	Dendritic cells, monocyte subpopulations	Functions as activation receptor upon binding dead cell debris. Promotes atherosclerosis and pancreatitis.
CD371	CLEC12A, CLL-1, MICL, DCAL-2	Monocytes, macrophages, myeloid dendritic cells, strong expression in B-ALL.	C-lectin receptor involved in antigen capturing. Regulates inflammation in response to cell death.

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List and summary of all human CD antigens from CD1a to CD371.