Markers for p53 measurement

​​​A comprehensive antibody panel of recombinant monoclonal antibodies to p53

Mostly known as a tumor suppressor protein responding to DNA damage, p53 coordinates a whole range of functions including stress response, transcription, and mitochondrial survival.

ab219089 is an antibody sampler panel containing antibodies against key modifications of p53.

FeaturesBenefits
Antibodies against several modifications of p53Complete quantification of total p53, mutant p53, phosphorylated p53, and acetylated p53
Monoclonal antibodiesPrecise specificity to site-specific modifications
Recombinant antibodiesExceptionally low variation between lots

Antibodies in this panel ( ab219089) include the following:

Unmodified p53

Mouse monoclonal to p53 [DO-1] (ab1101)

  • Knockout validated on CRISPR/Cas9-mediated HAP1 cells
  • Verified for ChIP, ICC/IF, ELISA, IHC-P, IHC-Fr, IP, WB, Flow Cyt
  • Reacts with Human
  • Cited in over 22 publications

​​​​Mutant p53

Recombinant rabbit monoclonal to Mutant p53 [Y5] (ab32049)

  • Marker of cancer progression
  • Verified use in WB, IP, IHC-P, ICC/IF, and Flow Cyt
  • Tested in Human
  • Cited in 6 publications

Phosphorylated p53

Recombinant rabbit monoclonal to p53 (phospho S20) [EPR2156(2)] (ab157454)

  • p53 is phosphorylated by CHEK2 at Serine 20 in response to DNA damage, which prevents ubiquitination by MDM2
  • Verified use in WB, and IP
  • Tested in Human


Recombinant rabbit monoclonal to p53 (phospho S46) [EP42Y] (ab76242)

  • p53 is phosphorylated on Serine 46 by HIPK2 upon UV irradiation
  • Verified use in WB, IP, IHC-P, and ICC/IF
  • Tested in Human


Recombinant rabbit monoclonal to p53 (phospho S392) [EP155Y] (ab33889)

  • p53 is phosphorylated on Serine 392 following UV irradiation (sans gamma irradiation)
  • Verified use in WB, IP, and IHC-P
  • Tested in human, mouse, and rat

Acetylated p53

Recombinant rabbit monoclonal to p53 (acetyl K382) [EPR358(2)] (ab75754)

  • Acetylation of Lysine 382 by CREBBP enhances transcriptional activity. Deacetylation of Lysine 382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence.
  • Verified use in WB, ICC, and IHC-P
  • Tested in human
  • 5 star average Abreview rating and cited in 10 publications



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