Overview

  • Product name

    Anti-Prion protease resistant protein 27-30 antibody
    See all Prion protease resistant protein 27-30 primary antibodies
  • Description

    Rabbit polyclonal to Prion protease resistant protein 27-30
  • Host species

    Rabbit
  • Specificity

    Recognizes PrPC, with the potential fo PrPSC detection.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Sheep, Cow
  • Immunogen

    Synthetic peptide corresponding to Human Prion protease resistant protein 27-30. Peptide derived from the C-terminus of third a-helical domain of human prion protein.
    Database link: P04156

  • Positive control

    • IHC-P: Human brain (cortex) tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 8.00
    Preservative: 0.05% Sodium azide
    Constituents: 0.32% Tris HCl, 1% BSA
  • Concentration information loading...
  • Purity

    Affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab230340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.

For immunohistochemistry on paraffin-embedded tissues, a buffer, pH6.0 is suggeted for antigen retrieval.

Target

  • Relevance

    The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein.
  • Cellular localization

    Cell Membrane; lipid-anchor; GPI-anchor
  • Database links

  • Alternative names

    • ASCR antibody
    • CD230 antibody
    • CD230 antigen antibody
    • CJD antibody
    • Creutzfeld Jakob disease antibody
    • Fatal familial insomnia antibody
    • Gerstmann Strausler Scheinker syndrome antibody
    • GSS antibody
    • MGC26679 antibody
    • Prion protease resistant protein antibody
    • Prion PrP antibody
    • PRIP antibody
    • PRNP antibody
    • PRP antibody
    • PrP 27 30 antibody
    • PrP27 30 antibody
    • PrP33 35C antibody
    • PrPc antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human brain (cortex) tissue stained for Prion protease resistant protein 27-30 with ab230340 at 1/100 dilution in immunohistochemical analysis.

References

ab230340 has not yet been referenced specifically in any publications.

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