Overview

  • Product name

  • Description

    Rabbit polyclonal to PRL-1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human PRL-1 aa 23-156.

  • Positive control

    • Human placenta tissue; Transfected HEK293T cell lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab121185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function

    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
  • Tissue specificity

    Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • Developmental stage

    Expressed in fetal liver.
  • Post-translational
    modifications

    Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
  • Cellular localization

    Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm > cytoskeleton > spindle. And mitotic spindle.
  • Information by UniProt
  • Database links

  • Alternative names

    • HH 72 antibody
    • HH72 antibody
    • Hypothetical protein DKFZp779M0721 antibody
    • Phosphatase of regenerating liver 1 antibody
    • PRL 1 antibody
    • PRL-1 antibody
    • PRL1 antibody
    • Protein tyrosine phosphatase PTPCAAX1 antibody
    • Protein tyrosine phosphatase type IVA 1 antibody
    • Protein tyrosine phosphatase type IVA member 1 antibody
    • Protein-tyrosine phosphatase 4a1 antibody
    • Protein-tyrosine phosphatase of regenerating liver 1 antibody
    • Protein-tyrosine phosphatase, type 4A, 1 antibody
    • PTP(CAAXI) antibody
    • Ptp4a1 antibody
    • PTPCAAX1 antibody
    • TP4A1_HUMAN antibody
    see all

Images

  • ab121185, at 1/75 dilution, staining PRL-1 in paraffin-embedded Human placenta tissue, by Immunohistochemistry.

  • All lanes : Anti-PRL-1 antibody (ab121185) at 1/250 dilution

    Lane 1 : Negative control (vector-only transfected HEK293T lysate)

    Lane 2 : PRL-1-transfected HEK293T over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa))

    Developed using the ECL technique.

References

ab121185 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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