Overview

  • Product name

    Anti-PRMT7 antibody [EPR13489] - N-terminal
    See all PRMT7 primary antibodies
  • Description

    Rabbit monoclonal [EPR13489] to PRMT7 - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human PRMT7 aa 1-100 (Cysteine residue). The exact sequence is proprietary.
    Database link: Q9NVM4

  • Positive control

    • HeLa, 293T, HepG2 and MCF-7 cell lysates
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab179822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 78 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function

      Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
    • Involvement in disease

      Defects in PRMT7 are associated with mild intellectual disabilityy, obesity and symmetrical shortening of the digits and posterior metacarpals and metatarsals. The phenotype is a phenocopy of pseudohypoparathyroidism (PHP).
    • Sequence similarities

      Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
      Contains 2 SAM-dependent MTase PRMT-type domains.
    • Cellular localization

      Cytoplasm, cytosol. Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • [Myelin basic protein]-arginine N-methyltransferase PRMT7 antibody
      • ANM7_HUMAN antibody
      • FLJ10640 antibody
      • Histone-arginine N-methyltransferase PRMT7 antibody
      • KIAA1933 antibody
      • Myelin basic protein arginine N methyltransferase antibody
      • OTTHUMP00000174863 antibody
      • PRMT7 antibody
      • Protein arginine methyltransferase 7 antibody
      • Protein arginine N-methyltransferase 7 antibody
      see all

    Images

    • All lanes : Anti-PRMT7 antibody [EPR13489] - N-terminal (ab179822) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : 293T cell lysate
      Lane 3 : HepG2 cell lysate
      Lane 4 : MCF-7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 78 kDa

    References

    ab179822 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab179822.
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