ABC-transporter inhibitor. Competitive MRP1 blocker. Pannexin channel blocker (IC50 = 150 μM). Can be used to block the efflux of intracellular dyes and indicators.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in ethanol to 75 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Lee J et al. A renal-like organic anion transport system in the ciliary epithelium of the bovine and human eye. Mol Pharmacol87:697-705 (2015).
Read more (PubMed: 25661037) »
Bao XQ et al. Squamosamide derivative FLZ protected tyrosine hydroxylase function in a chronic MPTP/probenecid mouse model of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol : (2015).
Read more (PubMed: 25678053) »
Singh D Neuropharmacological aspects of Crocus sativus L.: a review of preclinical studies and ongoing clinical research. CNS Neurol Disord Drug Targets : (2015).
Read more (PubMed: 25714974) »
Di Virgilio F et al. Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers. Cell Calcium11:57-62 (0).
Read more (PubMed: 2191781) »