Overview

  • Product name

    Probenecid, ABC-transporter inhibitor
  • Description

    ABC-transporter inhibitor. Competitive MRP1 blocker. Pannexin channel blocker.
  • Biological description

    ABC-transporter inhibitor. Competitive MRP1 blocker. Pannexin channel blocker (IC50 = 150 μM). Can be used to block the efflux of intracellular dyes and indicators.
  • Purity

    > 99%
  • CAS Number

    57-66-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[(Dipropylamino)sulfonyl]benzoic acid
  • Molecular weight

    285.36
  • Molecular formula

    C13H19NO4S
  • PubChem identifier

    4911
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 75 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lee J  et al. A renal-like organic anion transport system in the ciliary epithelium of the bovine and human eye. Mol Pharmacol 87:697-705 (2015). Read more (PubMed: 25661037) »
  • Bao XQ  et al. Squamosamide derivative FLZ protected tyrosine hydroxylase function in a chronic MPTP/probenecid mouse model of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol : (2015). Read more (PubMed: 25678053) »
  • Singh D Neuropharmacological aspects of Crocus sativus L.: a review of preclinical studies and ongoing clinical research. CNS Neurol Disord Drug Targets : (2015). Read more (PubMed: 25714974) »
  • Di Virgilio F  et al. Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers. Cell Calcium 11:57-62 (0). Read more (PubMed: 2191781) »
See 1 Publication for this product

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