Overview

  • Product name

    Procainamide hydrochloride, Sodium channel blocker
  • Description

    Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor.
  • Biological description

    Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (Ki = 7.2 μM). Antiarrhythmic in vivo. Limited ability to cross the blood-brain barrier.
  • Purity

    > 99%
  • CAS Number

    614-39-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lee BH  et al. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem 280:40749-56 (2005). Read more (PubMed: 16230360) »
  • Reinker S  et al. Effects of procainamide on membrane properties of thalamic neurons. Proc West Pharmacol Soc 44:89-92 (2001). Read more (PubMed: 11794008) »
  • Ellenbogen KA  et al. Procainamide: a perspective on its value and danger. Heart Dis Stroke 2:473-6 (1993). Read more (PubMed: 8137053) »
  • Zamponi GW  et al. Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation. Biophys J 65:2324-34 (1993). Read more (PubMed: 8312472) »

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