Key features and details
- Rabbit polyclonal to proCathepsin D
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-proCathepsin D antibody
See all proCathepsin D primary antibodies
DescriptionRabbit polyclonal to proCathepsin D
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Human
Recombinant full length protein corresponding to Human proCathepsin D aa 65-412.
Database link: P07339
- WB: A-549 cell lysate, mouse kidney and heart tissue lysates.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab186826 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 45 kDa.|
FunctionAcid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Involvement in diseaseDefects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
Sequence similaritiesBelongs to the peptidase A1 family.
Cellular localizationLysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
- CATD_HUMAN antibody
- cathepsin D (lysosomal aspartyl protease) antibody
- Cathepsin D antibody
All lanes : Anti-proCathepsin D antibody (ab186826) at 1/1000 dilution
Lane 1 : A-549 cell lysate
Lane 2 : Mouse kidney tissue lysate
Lane 3 : Mouse heart tissue lysate
Lysates/proteins at 25 µg per lane.
All lanes : HRP Goat Anti-Rabbit IgG (H+L)
Predicted band size: 45 kDa
Blocking buffer: 3% nonfat dry milk in TBST.
ab186826 has not yet been referenced specifically in any publications.