Key features and details
- Rabbit polyclonal to PRODH
- Suitable for: IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-PRODH antibody
See all PRODH primary antibodies
DescriptionRabbit polyclonal to PRODH
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 50% Glycerol, 0.01% BSA
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab203875 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
When using a fluorescent probe please use dilutions of 1/50-1/200.
FunctionConverts proline to delta-1-pyrroline-5-carboxylate.
Tissue specificityExpressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
PathwayAmino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Involvement in diseaseDefects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Sequence similaritiesBelongs to the proline oxidase family.
Cellular localizationMitochondrion matrix.
- Information by UniProt
- HSPOX2 antibody
- mitochondrial antibody
- P53 induced gene 6 protein antibody
Immunohistochemical analysis of formalin-fixed paraffin-embedded rat brain tissue, labeling PRODH using ab203875 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
Immunohistochemical analysis of formalin-fixed paraffin-embedded mouse kidney tissue, labeling PRODH using ab203875 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
ab203875 has not yet been referenced specifically in any publications.