• Product name
  • Description
    Goat polyclonal to PRODH
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 84-98 of Human PRODH

  • Positive control
    • Human Brain lysates



Our Abpromise guarantee covers the use of ab48001 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 60 kDa.
IHC-P Use a concentration of 3 - 6 µg/ml.


  • Function
    Converts proline to delta-1-pyrroline-5-carboxylate.
  • Tissue specificity
    Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
  • Pathway
    Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
  • Involvement in disease
    Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
    Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • Sequence similarities
    Belongs to the proline oxidase family.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • HSPOX2 antibody
    • mitochondrial antibody
    • P53 induced gene 6 protein antibody
    • p53-induced gene 6 protein antibody
    • PIG6 antibody
    • POX antibody
    • PROD_HUMAN antibody
    • PRODH 1 antibody
    • PRODH 2 antibody
    • PRODH antibody
    • PRODH1 antibody
    • PRODH2 antibody
    • Proline dehydrogenase antibody
    • proline dehydrogenase (oxidase) 1 antibody
    • proline dehydrogenase (proline oxidase) antibody
    • Proline dehydrogenase 1 antibody
    • Proline dehydrogenase 1, mitochondrial antibody
    • Proline oxidase 1 antibody
    • Proline oxidase 2 antibody
    • Proline oxidase antibody
    • Proline oxidase, mitochondrial antibody
    • Proline oxidase, mitochondrial precursor antibody
    • SCZD4 antibody
    • TP53I6 antibody
    • tumor protein p53 inducible protein 6 antibody
    see all


  • ab48001 at 3.8 µg/ml staining PRODH in Human cerebellum tissue by Immunohistochemistry (Formalin/PFA-Fixed paraffin-embedded sections).


This product has been referenced in:
  • Thompson T  et al. 1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53. Mol Cancer Ther 9:1158-68 (2010). WB ; Human . Read more (PubMed: 20406950) »
See 1 Publication for this product

Customer reviews and Q&As


Merci pour votre réponse.

Je viens de vous avoir envoyé le devis.

Je vous envoie ici aussi le code pour participer à l'offre de test en FACS - si jamais après validation en WB vous décidez de poursuivre avec le FACS.

Cette offre est pour tester le ab93210 en FACS. Le code de réduction correspondant est xx Ce code de réduction est utilisable sous 120 jours et pour l’achat d’un autre anticorps primaire.

Vous devez dans un premier temps soumettre une Abreview avec vos résultats en FACS en notant ce code dans la section « Additional notes ». Ce code sera ainsi activé et vous pourrez par la suite contacter notre service clientèle par téléphone pour passer votre prochaine commande, en vous munissant des informations suivantes : code de réduction, numéro de commande de ab93210.

Nous restons à votre disposition pour plus d’informations concernant cette offre promotionnelle. Dans l’attente de recevoir votre Abreview nous vous souhaitons bonne chance dans vos recherches.

Termes et Conditions : www.abcam.com/collaborationdiscount.

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