Product nameProdigiosin, apoptotic agent
DescriptionPotent apoptotic agent. Antibiotic agent.
Biological descriptionPotent apoptotic agent. Antibiotic agent. Induces caspase-dependent apoptosis. Inhibits mTORC1 and mTORC2. Reactivates p53. Inhibits iNOS expression. Shows anti-ischemic and antimalarial effects in vivo.
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in ethanol and in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Proteobacterium strain (Gamma)
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Hong B et al. Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53. Cancer Res 74:1153-65 (2014). Read more (PubMed: 24247721) »
- Chang CC et al. Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia. Toxicol Appl Pharmacol 257:137-47 (2011). Read more (PubMed: 21925195) »
- Ohkuma S et al. Prodigiosins uncouple lysosomal vacuolar-type ATPase through promotion of H+/Cl- symport. Biochem J 334 ( Pt 3):731-41 (1998). Read more (PubMed: 9729483) »