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    products/biochemicals/--bicuculline-methiodide-gabaa-antagonist-ab120108.pdf

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Neuroscience Neurotransmitter Amino Acids GABA
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(-)-Bicuculline methiodide, GABAA antagonist (ab120108)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - (-)-Bicuculline methiodide, GABA<sub>A</sub> antagonist (ab120108)

    Key features and details

    • GABAA antagonist
    • CAS Number: 40709-69-1
    • Soluble in water to 10 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      (-)-Bicuculline methiodide, GABAA antagonist
    • Description

      GABAA antagonist
    • CAS Number

      40709-69-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      [S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
    • Molecular weight

      509.29
    • Molecular formula

      C21H20INO6
    • PubChem identifier

      185826
    • Storage instructions

      Store at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 10 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      To be used on the same day after reconstitution.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      [I-].C[N+]5(C)CCc1cc6OCOc6cc1[C@@H]5[C@H]4OC(=O)c3c4ccc2OCOc23
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • GABA
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • GABA
      • GABAA
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • GABA
      • GABAA
      • Antagonists
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • GABA
      • GABAA
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • GABA
      • GABAA
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • GABA
      • GABAA
      • Biochemicals
      • Research Area
      • Schizophrenia
      • GABA
      • GABAA
      • Antagonists
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • GABA
      • GABAA
      • Biochemicals
      • Research Area
      • Stress / Anxiety
      • GABA
      • GABAA
      • Antagonists

    Images

    • Chemical Structure - (-)-Bicuculline methiodide, GABA<sub>A</sub> antagonist (ab120108)
      Chemical Structure - (-)-Bicuculline methiodide, GABAA antagonist (ab120108)
      2D chemical structure image of ab120108, (-)-Bicuculline methiodide, GABAA antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (29)

    Publishing research using ab120108? Please let us know so that we can cite the reference in this datasheet.

    ab120108 has been referenced in 29 publications.

    • Yong XLH  et al. Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIa phosphorylation of the GluN2A subunit. Cell Rep 36:109338 (2021). PubMed: 34233182
    • Conde-Dusman MJ  et al. Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. Elife 10:N/A (2021). PubMed: 34787081
    • Kumar R  et al. Astrocytic Regulation of Synchronous Bursting in Cortical Cultures: From Local to Global. Cereb Cortex Commun 1:tgaa053 (2020). PubMed: 34296118
    • Booker SA  et al. Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network. Elife 9:N/A (2020). PubMed: 32073397
    • Garay PM  et al. RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling. Cell Rep 32:108002 (2020). PubMed: 32783930
    View all Publications for this product

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