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(+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (40)

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Chemical Structure - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)
  • Functional Studies - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)

Key features and details

  • Non-competitive NMDA antagonist
  • CAS Number: 77086-22-7
  • Soluble in water to 25 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist
  • Description

    Non-competitive NMDA antagonist
  • Alternative names

    • Dizocilpine
  • Biological description

    Potent, selective non-competitive NMDA receptor antagonist. Open channel blocker of the NMDA receptor operated ion channel.

    Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration.

  • CAS Number

    77086-22-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate
  • Molecular weight

    337.37
  • Molecular formula

    C16H15N.C4H4O4
  • PubChem identifier

    6420042
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)/C=CC(=O)O.C[C@@]42N[C@H](Cc1ccccc12)c3ccccc34
  • Source

    Synthetic

  • Research areas

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Images

  • Chemical Structure - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)
    Chemical Structure - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)
    2D chemical structure image of ab120027, (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist
  • Functional Studies - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)
    Functional Studies - (+)-MK 801 maleate (Dizocilpine), Non-competitive NMDA antagonist (ab120027)Image from Fowler SW et al., Neurobiol Learn Mem. 2010;95(1):73-9. Fig 2(B).; doi: 10.1016/j.nlm.2010.11.009 with permission from Elsevier.
    CDPPB does not influence spontaneous locomotor activity but attenuates MK-801-induced hyperlocomotion. Animals were injected (s.c./i.p.) with PBS/Vehicle (0/0), 0.2 mg/kg MK-801/Vehicle (0.2/0), 0.2 mg/kg MK-801/3 mg/kg CDPPB (0.2/3) or 0.2 mg/kg MK-801/10 mg/kg CDPPB (0.2/10) 20 minutes before being placed in the activity chamber. Activity was recorded for 30 minutes. Data are expressed as mean ± SEM of distance traveled (n=6-7). **p<0.01 vs. 0.2 mg/kg MK-801/Vehicle group (One-way ANOVA, Bonferroni’s posttest).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (40)

Publishing research using ab120027? Please let us know so that we can cite the reference in this datasheet.

ab120027 has been referenced in 40 publications.

  • Pampaloni NP  et al. Slow AMPA receptors in hippocampal principal cells. Cell Rep 36:109496 (2021). PubMed: 34348150
  • Lee GS  et al. Behavioral and Neuroanatomical Consequences of Cell-Type Specific Loss of Dopamine D2 Receptors in the Mouse Cerebral Cortex. Front Behav Neurosci 15:815713 (2021). PubMed: 35095443
  • Chen J  et al. Nicotine Suppresses the Invasiveness of Human Trophoblasts by Downregulation of CXCL12 Expression through the Alpha-7 Subunit of the Nicotinic Acetylcholine Receptor. Reprod Sci 27:916-924 (2020). PubMed: 31933163
  • Liu CW  et al. Hypothermia but not NMDA receptor antagonism protects against stroke induced by distal middle cerebral arterial occlusion in mice. PLoS One 15:e0229499 (2020). PubMed: 32126102
  • Tognatta R  et al. Astrocytes Are Required for Oligodendrocyte Survival and Maintenance of Myelin Compaction and Integrity. Front Cell Neurosci 14:74 (2020). PubMed: 32300294
View all Publications for this product

Customer reviews and Q&As

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Question

Product code: 120027
Inquiry: Hi, I would like to know the price of this item? Thanks

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Abcam community

Verified customer

Asked on May 29 2013

Answer

Please contact our Australian distributor for the price;

Sapphire Bioscience Pty Ltd
126 Cope Street
Waterloo - NSW
2017
Australia

Read More

Abcam Scientific Support

Answered on May 29 2013

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