1400W, iNOS inhibitor (ab120165)
Key features and details
- Selective iNOS inhibitor
- CAS Number: 214358-33-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
1400W, iNOS inhibitor -
Description
Selective iNOS inhibitor -
Biological description
Selective iNOS inhibitor, 5000-fold selective over eNOS (Kd values are ≤7 nM, 2 μM and 50 μM at human iNOS, nNOS and eNOS, respectively).
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CAS Number
214358-33-5 -
Chemical structure
Properties
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Chemical name
N-[3-(Aminomethyl)benzyl]acetamidine dihydrochloride -
Molecular weight
250.17 -
Molecular formula
C10H15N3.2HCl -
PubChem identifier
2733515 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.CC(=N)NCc1cccc(c1)CN -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- NOS
- Inhibitors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- Nitric oxide signaling
- NOS
- Inhibitors
Associated products
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Related Products
Images
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Chemical Structure - 1400W, iNOS inhibitor (ab120165)2D chemical structure image of ab120165, 1400W, iNOS inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab120165 has been referenced in 5 publications.
- Simpson DS et al. Interferon-? primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 55:423-441.e9 (2022). PubMed: 35139355
- Xian Bo S et al. An Inducible Nitric Oxide Synthase Dimerization Inhibitor Prevents the Progression of Osteoarthritis. Front Pharmacol 13:861183 (2022). PubMed: 35910349
- Liu L et al. Inhibition of inducible nitric oxide synthase improved erectile dysfunction in rats with type 1 diabetes. Andrologia 53:e14138 (2021). PubMed: 34137064
- Jiang L et al. Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate. Redox Biol 43:101989 (2021). PubMed: 33940548
- Tanemoto R et al. The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1ß-treated hepatocytes. Biochem Biophys Rep 2:153-159 (2015). PubMed: 29124157
