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2-APB, Ca2+ release modulator (ab120124)

Submit a review Submit a question References (13)
Chemical Structure - 2-APB, Ca<sup>2+</sup> release modulator (ab120124)
  • Functional Studies - 2-APB, Ca<sup>2+</sup> release modulator (ab120124)

Key features and details

  • Ca2+ release modulator
  • CAS Number: 524-95-8
  • Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    2-APB, Ca2+ release modulator

  • Description

    Ca2+ release modulator

  • Biological description

    Cell-permeable, allosteric inhibitor of D-myo-inositol 1,4,5-trisphosphate (IP3) -induced Ca2+ release . Inhibits IP3-induced Ca2+ release without affecting IP3 receptor binding. Blocks store operated Ca2+ entry.

  • CAS Number

    524-95-8

  • Chemical structure

    Chemical Structure

Properties

Images

  • Chemical Structure - 2-APB, Ca<sup>2+</sup> release modulator (ab120124)
    Chemical Structure - 2-APB, Ca2+ release modulator (ab120124)
    2D chemical structure image of ab120124, 2-APB, Ca2+ release modulator
  • Functional Studies - 2-APB, Ca<sup>2+</sup> release modulator (ab120124)
    Functional Studies - 2-APB, Ca2+ release modulator (ab120124)Kubota et al PLoS One. 2014; 9(9): e106316. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    Induction of mGluR1-mediated inward current requires activation of TRPC1 but not TRPC3 in MLIs.

    Time courses of the effects of SKF96365 (black circles, 30 µM, n = 4) and 2-APB (gray circles, 100 µM, n = 5) on the DHPG-induced inward current. A black bar indicates the time of drug application.

    (From Figure 2 B of Kubota et al).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (13)

Publishing research using ab120124? Please let us know so that we can cite the reference in this datasheet.

ab120124 has been referenced in 13 publications.

  • Andriule I  et al. Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart. Sci Rep 11:15445 (2021). PubMed: 34326388
  • King CM  et al. Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals. Cell Rep 30:3466-3477.e4 (2020). PubMed: 32160550
  • Bai D  et al. Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication. Virology 539:38-48 (2020). PubMed: 31670218
  • Li L  et al. TRPM7 modulates macrophage polarization by STAT1/STAT6 pathways in RAW264.7 cells. Biochem Biophys Res Commun 533:692-697 (2020). PubMed: 33153718
  • Shen Y  et al. Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions. Nat Commun 10:2924 (2019). PubMed: 31266950
View all Publications for this product

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