For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Customized Products & Partnerships
    Customized Products & Partnerships

    Customized products and commercial partnerships to accelerate your diagnostic and therapeutic programs.

    Customized products

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

  1. Link

    23-cis-piperidine-dicarboxylic-acid-cis-pda-ionotropic-receptor-antagonist-ab120038.pdf

  1. Send me a copy of this email
    I agree to the terms and conditions.
Neuroscience Neurotransmitter Amino Acids Glutamate
Share by email

2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist (ab120038)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (2)References (1)

Product price, shipping and contact information

Currently unavailable

Sorry, we can't display this right now.

Please contact us to place your order, or try again later.

 

Loading size & price…

 

Shipping and order information

Shipping info

Promotion Information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Chemical Structure - 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist (ab120038)

    Key features and details

    • Ionotropic receptor antagonist
    • CAS Number: 46026-75-9
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist
    • Description

      Ionotropic receptor antagonist
    • Alternative names

      • cis PDA
    • Biological description

      General ionotropic receptor antagonist. Blocks NMDA, AMPA and kainate mediated responses. Also acts as a partial NMDA receptor agonist in the in vitro rat cerebellar cGMP model.

      Also available in simple stock solutions (ab146697) - add 1 ml of water to get an exact, ready-to-use concentration.

    • CAS Number

      46026-75-9
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      cis-Piperidine-2,3-dicarboxylic acid
    • Molecular weight

      173.17
    • Molecular formula

      C7H11NO4
    • PubChem identifier

      1226
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      OC(=O)C1CCCNC1C(=O)O
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • Glutamate
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Glutamate Receptors
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Amino Acid
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Addiction
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Depression
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Schizophrenia
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Biochemicals
      • Research Area
      • Stroke
      • Glutamate
      • Broad spectrum / non-selective
      • Antagonists
      • Neuroscience
      • Processes

    Images

    • Chemical Structure - 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist (ab120038)
      Chemical Structure - 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist (ab120038)
      2D chemical structure image of ab120038, 2,3 cis-Piperidine dicarboxylic acid (cis PDA), Ionotropic receptor antagonist

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (1)

    Publishing research using ab120038? Please let us know so that we can cite the reference in this datasheet.

    ab120038 has been referenced in 1 publication.

    • Umino Y  et al. Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision. J Neurosci 39:3041-3056 (2019). PubMed: 30737308

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-2 of 2 Abreviews or Q&A

    Question

    1) Can I use PBS to dissolve both substances?
    2) How much volume of 1M NaOH should I use to neutralize the solution?
    3) Can I prepare a cocktail of both reagents ?

    Read More

    Abcam community

    Verified customer

    Asked on Mar 21 2012

    Answer

    Thank you for your enquiry regarding L-AP4 and cis-PDA. The lab send me the following information:

    As we do not currently undertake any of our own research we can only offer advice based on published literature. Both L-AP4 and cis-PDA have been previously dissolved in PBS for use in both rats and rabbits, respectively. It is therefore reasonable to believe that you will be able to use both compounds with PBS in your research. I have attached two papers for your reference.
    I can also provide the following information in reference to neutralizing solutions using 1M NaOH.

    L-AP4
    5.46 μl (1 mg)
    54.6 μl (10 mg)
    273.07 μl (50 mg)

    cis-PDA
    288.73 μl (50 mg)
    1.44 ml (250 mg)


    These values can be calculated using the following formula:
    { Mass of compound (mg) x 1000 } / { MW of compound x [NaOH] } = Vol (ml) NaOH
    In reference to your third point, unfortunately we have not come across previous literature describing a combination of the two compounds used as a cocktail. Since we do not test these combinations in-house I cannot guarantee any in vivo responses, however it is likely that at reasonable physiological concentrations you should see no adverse effects. Please note that you will need to add enough NaOH to neutralize both compounds.
    Please do not hesitate to contact us again if you require further assistance.

    Read More

    Abcam Scientific Support

    Answered on Mar 21 2012

    Question

    ASC038 BATCH 0612341

    Can you tell me if the product above is:

    1) Dextrorotatory or Levorotatory, or the mixture of both?

    2) If the compound is represented in the R and S system, is this compound (2R,3S0) cis Piperidine dicarboxylic acid or (2S,3R) cis Piperidine dicarboxylic acid or the mixture?

    Read More

    Abcam community

    Verified customer

    Asked on Feb 08 2012

    Answer

    I can confirm that cis Piperidine dicarboxylic acid (Asc-038) is a mixture of both Dextrorotatory and Levorotatory and is represented as the mixture.
    I hope this is helpful. Please contact me again if you have any further questions.

    Read More

    Abcam Scientific Support

    Answered on Feb 08 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

    Get resources and offers direct to your inbox Sign up
    A-Z by research area
    • Cancer
    • Cardiovascular
    • Cell biology
    • Developmental biology
    • Epigenetics & Nuclear signaling
    • Immunology
    • Metabolism
    • Microbiology
    • Neuroscience
    • Signal transduction
    • Stem cells
    A-Z by product type
    • Primary antibodies
    • Secondary antibodies
    • Biochemicals
    • Isotype controls
    • Flow cytometry multi-color selector
    • Kits
    • Loading controls
    • Lysates
    • Peptides
    • Proteins
    • Slides
    • Tags and cell markers
    • Tools & Reagents
    Help & support
    • Support
    • Make an Inquiry
    • Protocols & troubleshooting
    • Placing an order
    • RabMAb products
    • Biochemical product FAQs
    • Training
    • Browse by Target
    Company
    • Corporate site
    • Investor relations
    • Company news
    • Careers
    • About us
    • Blog
    Events
    • Tradeshows
    • Conferences
    International websites
    • abcam.cn
    • abcam.co.jp

    Join with us

    • LinkedIn
    • facebook
    • Twitter
    • YouTube
    • Terms of sale
    • Website terms of use
    • Cookie policy
    • Privacy policy
    • Legal
    • Modern slavery statement
    © 1998-2023 Abcam plc. All rights reserved.