4-Hydroxynonenal, Lipid peroxidation marker (ab141502)
Key features and details
- Lipid peroxidation marker
- CAS Number: 75899-68-2
- Purity: > 97%
Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
4-Hydroxynonenal, Lipid peroxidation marker -
Description
Lipid peroxidation marker -
Biological description
Marker of lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation. Range of biological effects such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. Active in vivo.
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Purity
> 97% -
CAS Number
75899-68-2 -
Chemical structure
Properties
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Chemical name
(E)-4-Hydroxynon-2-enal
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Molecular weight
156.22 -
Molecular formula
C9H16O2 -
PubChem identifier
5283344 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCC(C=CC=O)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - 4-Hydroxynonenal, Lipid peroxidation marker (ab141502)2D chemical structure image of ab141502, 4-Hydroxynonenal, Lipid peroxidation marker
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Functional Studies - 4-Hydroxynonenal, Lipid peroxidation marker (ab141502)Bruells et al PLoS One. 2014 Jan 27;9(1):e87460. doi: 10.1371/journal.pone.0087460. eCollection 2014. Fig 3. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Western blot results of biomarkers of protein synthesis, proteolysis and oxidative stress in the diaphragm.
Panel B) The levels of 4-hydroxynonenal (4- HNE) were analyzed as an indicator of lipid peroxidation via Western blotting. A representative blot for 4-HNE protein conjugates is shown above the graph (Con n = 8, CMV n = 7, Ext 12 n = 8, Ext24 n = 8). C/D) Calpain (C) (Con n = 6, CMV n = 7, Ext 12 n = 7, Ext24 n = 8) and caspase-3.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab141502 has been referenced in 3 publications.
- Cao S et al. A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis. Biochem Biophys Res Commun 522:518-524 (2020). PubMed: 31784085
- Ilari S et al. Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control. Pharmacol Res 157:104851 (2020). PubMed: 32423865
- Niimi N et al. A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism. J Neurochem 144:710-722 (2018). PubMed: 29238976