5-Azacytidine, DNMT1 inhibitor (ab142744)
Key features and details
- Potent DNMT1 inhibitor. Induces DNA hypomethylation.
- CAS Number: 320-67-2
- Purity: > 98%
- Soluble in water to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
5-Azacytidine, DNMT1 inhibitor -
Description
Potent DNMT1 inhibitor. Induces DNA hypomethylation. -
Alternative names
- 5-AzadCyD
- Dacogen
- NSC 102816
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Purity
> 98% -
CAS Number
320-67-2 -
Chemical structure
Properties
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Chemical name
4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one -
Molecular weight
244.21 -
Molecular formula
C8H12N4O5 -
PubChem identifier
9444 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM and in DMSO to 100 mM -
Handling
Unstable; make up solutions fresh and use immediately.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Images
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Chemical Structure - 5-Azacytidine, DNMT1 inhibitor (ab142744)2D chemical structure image of ab142744, 5-Azacytidine, DNMT1 inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab142744 has been referenced in 5 publications.
- Schwenzer H et al. LARP1 isoform expression in human cancer cell lines. RNA Biol 18:237-247 (2021). PubMed: 32286153
- Alarcón MA et al. The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer. Int J Mol Sci 21:N/A (2020). PubMed: 33322837
- Chen J et al. 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis. Cancer Manag Res 11:9517-9528 (2019). PubMed: 31807076
- Fort RS et al. Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth. BMC Cancer 18:127 (2018). PubMed: 29394925
- Jacobs AH The skin in childhood. Hosp Pract 12:91-112 (1977). PubMed: 142744