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    products/biochemicals/8-4-chlorophenylthioadenosine-35-cyclic-monophosphate-8-cpt-camp-cell-permeable-camp-analog-ab120424.pdf

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Signal Transduction Protein Phosphorylation Ser / Thr Kinases PKA
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8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)
  • Functional Studies - 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)

Key features and details

  • Cell permeable cAMP analog, protein kinase modulator
  • CAS Number: 93882-12-3
  • Soluble in water to 50 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog.
  • Description

    Cell permeable cAMP analog, protein kinase modulator
  • Alternative names

    • 8-CPT-cAMP
  • CAS Number

    93882-12-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-(4-Chlorophenylthio)-adenosine-3',5'-cyclic monophosphate sodium salt
  • Molecular weight

    493.79
  • Molecular formula

    C16H14ClN5NaO6PS
  • PubChem identifier

    23672705
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SC5=CC=C(C=C5)Cl)N)O)OP(=O)(O1)[O-].[Na+]
  • Source

    Synthetic

  • Research areas

    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • PKA
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • Other Kinases
    • Biochemicals
    • Product Range
    • Just Add Water
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Kinase
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Kinase
    • Protein Kinase G
    • Activators
    • Biochemicals
    • Pharmacology
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Signal transduction
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators
    • Biochemicals
    • Research Area
    • Cancer
    • Signal transduction
    • Inositol & cAMP signaling
    • cAMP
    • Biochemicals
    • Research Area
    • Cancer
    • Signal transduction
    • Inositol & cAMP signaling
    • Protein Kinase A
    • Activators

Images

  • Chemical Structure - 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)
    Chemical Structure - 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)
    2D chemical structure image of ab120424, 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog.
  • Functional Studies - 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)
    Functional Studies - 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. (ab120424)
    1e7 3T3-L1 cells were treated for 15 minutes with 1 µM dexamethasone (ab120743) and 1 µg x mL-1 insulin (ab123768) with the addition of 50 µM forskolin (ab120058), 0.5 mM IBMX (ab120840) or 0.1 mM 8-CPT-cAMP (ab120424), extracted according to the protocol. Lysates were diluted 50-fold, and tested in duplicates (+/-SD).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (3)

Publishing research using ab120424? Please let us know so that we can cite the reference in this datasheet.

ab120424 has been referenced in 3 publications.

  • Reddy GR  et al. Deciphering cellular signals in adult mouse sinoatrial node cells. iScience 25:103693 (2022). PubMed: 35036877
  • Gray KM  et al. Quantitatively relating brain endothelial cell-cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program. Fluids Barriers CNS 17:16 (2020). PubMed: 32046757
  • Morad G  et al. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano 13:13853-13865 (2019). PubMed: 31479239

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