8-Br-cAMP (8-Bromo-cAMP), PKA activator (ab141448)
Key features and details
- cAMP analog. PKA activator.
- CAS Number: 76939-46-3
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
8-Br-cAMP (8-Bromo-cAMP), PKA activator -
Description
cAMP analog. PKA activator. -
Alternative names
- 8-Bromo-cAMP
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Purity
> 99% -
CAS Number
76939-46-3 -
Chemical structure
Properties
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Chemical name
8-Bromoadenosine-3′,5′-cyclic monophosphate sodium salt -
Molecular weight
430.09 -
Molecular formula
C10H10BrN5NaO6P -
PubChem identifier
23712387 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1C2C(C(C(O2)N3C4=C(C(=NC=N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+] -
Source
Synthetic
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Research areas
Images
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Chemical Structure - 8-Br-cAMP (8-Bromo-cAMP), PKA activator (ab141448)2D chemical structure image of ab141448, 8-Br-cAMP (8-Bromo-cAMP), PKA activator
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (6)
ab141448 has been referenced in 6 publications.
- Han M et al. Increased expression of HMGB1 in the implantation phase endometrium is related to recurrent implantation failure. Mol Biol Rep 49:1701-1710 (2022). PubMed: 35031923
- Chen Y et al. Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway. Front Physiol 12:642274 (2021). PubMed: 33868005
- Zhou M et al. Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization. J Adv Res 30:15-25 (2021). PubMed: 34026283
- Zhou X et al. Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity. Front Cell Dev Biol 8:105 (2020). PubMed: 32158757
- Tishchenko A et al. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers (Basel) 12:N/A (2020). PubMed: 33003486
- Zhou M et al. miR-196a overexpression activates the MEK/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis. Hum Reprod N/A:N/A (2016). PubMed: 27619769