8-Br-cGMP (8-Bromo-cGMP), PKG activator (ab141449)
Key features and details
- Cell permeable cGMP analog. PKG activator.
- CAS Number: 51116-01-9
- Purity: > 95%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
8-Br-cGMP (8-Bromo-cGMP), PKG activator -
Description
Cell permeable cGMP analog. PKG activator. -
Purity
> 95% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1838 8-Br-cGMP. 1838-25 is the same size as the 25 mg size of ab141449.
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CAS Number
51116-01-9 -
Chemical structure
Properties
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Chemical name
2-Amino-8-bromo-9-(7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one sodium salt -
Molecular weight
446.08 -
Molecular formula
C10H10BrN5NaO7P -
PubChem identifier
44134592 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+] -
Source
Synthetic
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Research areas
Associated products
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Related Products
Images
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Chemical Structure - 8-Br-cGMP (8-Bromo-cGMP), PKG activator (ab141449)2D chemical structure image of ab141449, 8-Br-cGMP (8-Bromo-cGMP), PKG activator
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab141449 has been referenced in 2 publications.
- Cao S et al. Effects of cGMP/Akt/GSK-3β signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing. Front Physiol 13:861981 (2022). PubMed: 36060704
- Gu M et al. Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart. Front Cell Dev Biol 9:774185 (2021). PubMed: 35155444