8-Br-cGMP (8-Bromo-cGMP), PKG activator (ab141449)
Key features and details
- Cell permeable cGMP analog. PKG activator.
- CAS Number: 51116-01-9
- Purity: > 95%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Product name8-Br-cGMP (8-Bromo-cGMP), PKG activator
DescriptionCell permeable cGMP analog. PKG activator.
This product is manufactured by BioVision, an Abcam company and was previously called 1838 8-Br-cGMP. 1838-25 is the same size as the 25 mg size of ab141449.
Chemical name2-Amino-8-bromo-9-(7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-3H-purin-6-one sodium salt
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
ab141449 has been referenced in 2 publications.
- Cao S et al. Effects of cGMP/Akt/GSK-3β signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing. Front Physiol 13:861981 (2022). PubMed: 36060704
- Gu M et al. Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart. Front Cell Dev Biol 9:774185 (2021). PubMed: 35155444