9-cis-Retinoic acid, Endogenous retinoic acid receptor agonist (ab141023)
Key features and details
- High affinity, endogenous retinoic acid receptor agonist
- CAS Number: 5300-03-8
- Purity: > 98%
- Soluble in DMSO to 25 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
9-cis-Retinoic acid, Endogenous retinoic acid receptor agonist -
Description
High affinity, endogenous retinoic acid receptor agonist -
Biological description
High affinity, endogenous retinoic acid receptor (RAR) agonist (IC50= 14 nM for RARα, RARβ and RARγ). Active metabolite of vitamin A. Acts as a transcription factor to regulate the growth and differentiation of normal and malignant cells and capable of inhibiting prostaglandin-endoperoxide synthase 2 expression. -
Purity
> 98% -
CAS Number
5300-03-8 -
Chemical structure
Properties
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Chemical name
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)nona-2E,4E,6Z,8E-tetraenoic acid -
Molecular weight
300.44 -
Molecular formula
C20H28O2 -
PubChem identifier
449171 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC=1CCCC(C)(C)C=1/C=C/C(/C)=C\C=C\C(\C)=C\C(=O)O -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Co-activators/co-repressors
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Images
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Chemical Structure - 9-cis-Retinoic acid, Endogenous retinoic acid receptor agonist (ab141023)2D chemical structure image of ab141023, 9-cis-Retinoic acid, Endogenous retinoic acid receptor agonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab141023 has been referenced in 1 publication.
- Zhao H et al. Intranasal delivery of 9-cis retinoic acid reduces beta-amyloid deposition via inhibiting astrocyte-mediated inflammation. Aging (Albany NY) 12:5469-5478 (2020). PubMed: 32209731