AGK2, sirtuin2 (SIRT2) inhibitor (ab142073)
Key features and details
- Selective reversible cell-permeable sirtuin2 (SIRT2) inhibitor
- CAS Number: 304896-28-4
- Purity: > 95%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AGK2, sirtuin2 (SIRT2) inhibitor -
Description
Selective reversible cell-permeable sirtuin2 (SIRT2) inhibitor -
Purity
> 95% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1651 SIRT2 Inhibitor, AGK2. 1651-10 is the same size as the 10 mg size of ab142073.
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CAS Number
304896-28-4 -
Chemical structure
Properties
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Chemical name
(E)-2-Cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-5-ylprop-2-enamide -
Molecular weight
434.27 -
Molecular formula
C23H13Cl2N3O2 -
PubChem identifier
2130404 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab142073 has been referenced in 1 publication.
- Deng J et al. Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways. Bioengineered 12:7975-7984 (2021). PubMed: 34565300