alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist (ab120189)
Key features and details
- Endogenous melanocortin receptor agonist
- CAS Number: 581-05-5
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist -
Description
Endogenous melanocortin receptor agonist -
Alternative names
- α-Melanocyte-stimulating hormone
- α-Melanotropin
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Biological description
Endogenous melanocortin receptor agonist involved in feeding, homeostasis, body weight and inflammation.
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CAS Number
581-05-5 -
Chemical structure
Properties
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Molecular weight
1664.89 -
Molecular formula
C77H109N21O19S -
Sequence
SYSMEHFRWGKPV (Modifications: N-terminal acetyl; C-terminal amide) -
PubChem identifier
16132144 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Receptors & Transporters
- Peptide Receptors
- Melanocyte Stimulating Hormone
- Agonists
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Biochemicals
- Research Area
- Pain & inflammation
- Peptide Receptors
- Melanocyte Stimulating Hormone
- Agonists
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab120189 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| Notes |
|---|
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Functional Studies
Use at an assay dependent concentration. |
Images
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Chemical Structure - alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist (ab120189)2D chemical structure image of ab120189, alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist
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Functional Studies - alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist (ab120189)ab24851 staining cAMP in MALME-3M cells treated with α-MSH (ab120189), by ICC/IF. Increase of cAMP correlates with increased concentration of α-MSH as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120189 (α-MSH) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab24851 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab120189 has been referenced in 1 publication.
- Löw K et al. A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs. FEBS Lett 594:2840-2866 (2020). PubMed: 32506501