AMD3100 octahydrochloride, CXCR4 antagonist (ab120718)
Key features and details
- Highly selective CXCR4 antagonist
- CAS Number: 155148-31-5
- Purity: > 99%
Soluble in PBS, pH 7.2, at 10 mg/ml.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AMD3100 octahydrochloride, CXCR4 antagonist -
Description
Highly selective CXCR4 antagonist -
Alternative names
- AMD 3100
- JM 3100
- Mobozil
- SID 791
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Biological description
Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF-
1 (CXCL12).
It suppresses infection by HIV with an IC50 value of 1-
10 ng/ml with selectivity toward CXCR4- tropic virus. Plerixafor mobilizes hematopoietic stem and progenitor cells for transplant better than G- CSF alone. It also increases T- cell trafficking in the blood and spleen as well as the central nervous system. Plerixafor regulates the growth of primary and metastic breast cancer cells and inhibits dissemination of ovarian carcinoma cells. -
Purity
> 99% -
CAS Number
155148-31-5 -
Chemical structure
Properties
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Chemical name
1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride
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Molecular weight
794.48 -
Molecular formula
C28H54N8.8HCl -
PubChem identifier
65014 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in PBS, pH 7.2, at 10 mg/ml.
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl -
Source
Synthetic
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Research areas
Images
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Chemical Structure - AMD3100 octahydrochloride, CXCR4 antagonist (ab120718)2D chemical structure image of ab120718, AMD3100 octahydrochloride, CXCR4 antagonist
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Cellular activation - AMD3100 octahydrochloride, CXCR4 antagonist (ab120718)Image from Lee IP, et al. Plos One, 9(10), e109803. Fig 3B,; doi: 10.1371/journal.pone.0109803Uninfected control DCs were treated with MeAIB, MSO, inhibitors of CXCR4 (AMD3100), PI3K (LY294002, ab120243) or Rho kinase (Y27632, ab120129), or Gln starvation for 2 hours before assessing migration to 100 ng/ml SDF-1 α. Chemotactic index (CI) is defined as the fold increase in the number of migrating DCs to SDF-1 α over the spontaneous migration. One-way ANOVA reveals an effect of pharmacological treatments on the SDF-1 α-induced migration (F(6,44) = 6.700, P<0.001). Asterisks indicate P<0.05 (Dunnett's post hoc).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (23)
ab120718 has been referenced in 23 publications.
- Lin YN et al. Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity. Oncoimmunology 11:2027136 (2022). PubMed: 35127250
- Qin H et al. Inhibition of SDF-1/CXCR4 Axis to Alleviate Abnormal Bone Formation and Angiogenesis Could Improve the Subchondral Bone Microenvironment in Osteoarthritis. Biomed Res Int 2021:8852574 (2021). PubMed: 34136574
- Cugurra A et al. Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma. Science 373:N/A (2021). PubMed: 34083447
- Umezu K et al. Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle. PLoS One 15:e0232536 (2020). PubMed: 32353075
- Ito N et al. Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis. Am J Physiol Renal Physiol 318:F741-F753 (2020). PubMed: 32068458