For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Customized Products & Partnerships
    Customized Products & Partnerships

    Customized products and commercial partnerships to accelerate your diagnostic and therapeutic programs.

    Customized products

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

  1. Link

    products/biochemicals/angiotensin-ii-human-vasoconstrictor-peptide-ab120183.pdf

  1. Send me a copy of this email
    I agree to the terms and conditions.
Signal Transduction Signaling Pathway Lipid Signaling PLC
Share by email

Angiotensin II (human), Vasoconstrictor peptide (ab120183)

  • Datasheet
  • SDS
  • COA
Reviews (1)Q&A (1)References (12)

Product price, shipping and contact information

Currently unavailable

Sorry, we can't display this right now.

Please contact us to place your order, or try again later.

 

Loading size & price…

 

Shipping and order information

Shipping info

Promotion Information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Chemical Structure - Angiotensin II (human), Vasoconstrictor peptide (ab120183)

    Key features and details

    • Vasoconstrictor peptide
    • CAS Number: 4474-91-3
    • Soluble in water to 1mg/ml
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Angiotensin II (human), Vasoconstrictor peptide
    • Description

      Vasoconstrictor peptide
    • Biological description

      Endogenous peptide involved in body water and electrolyte homeostasis, blood pressure, cyclicity of reproductive hormones and sexual behaviours, and the regulation of pituitary gland hormones.

    • CAS Number

      4474-91-3
    • Chemical structure

      Chemical Structure

    Properties

    • Molecular weight

      1046.18
    • Molecular formula

      C50H71N13O12
    • Sequence

      DRVYIHPF
    • PubChem identifier

      172198
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 1mg/ml
    • Handling

      This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • Source

      Synthetic

    • Research areas

      • Signal Transduction
      • Signaling Pathway
      • Lipid Signaling
      • PLC
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Cancer
      • Invasion/microenvironment
      • Angiogenesis
      • Angiogenic growth factors
      • Cardiovascular
      • Atherosclerosis
      • Apoptosis
      • Cardiovascular
      • Blood
      • Blood Pressure regulation
      • Cancer
      • Cancer Metabolism
      • Cellular metabolic process
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Bioactive peptides
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism
      • Biochemicals
      • Research Area
      • Hypertension
      • Peptide Receptors
      • Angiotensin
      • Agonists
      • Biochemicals
      • Research Area
      • Obesity
      • Peptide Receptors
      • Angiotensin
      • Agonists
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Peptide Receptors
      • Angiotensin
      • Agonists
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Peptide Receptors
      • Angiotensin
      • Agonists
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Peptide Receptors
      • Angiotensin
      • AT2

    Images

    • Chemical Structure - Angiotensin II (human), Vasoconstrictor peptide (ab120183)
      Chemical Structure - Angiotensin II (human), Vasoconstrictor peptide (ab120183)
      2D chemical structure image of ab120183, Angiotensin II (human), Vasoconstrictor peptide

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (12)

    Publishing research using ab120183? Please let us know so that we can cite the reference in this datasheet.

    ab120183 has been referenced in 12 publications.

    • Guo J  et al. Metformin protects against abdominal aortic aneurysm by Atg7-induced autophagy. Adv Clin Exp Med 31:59-69 (2022). PubMed: 34714980
    • Wang L  et al. Adropin inhibits the phenotypic modulation and proliferation of vascular smooth muscle cells during neointimal hyperplasia by activating the AMPK/ACC signaling pathway. Exp Ther Med 21:560 (2021). PubMed: 33850532
    • Bao Q  et al. Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis. Elife 9:N/A (2020). PubMed: 31934850
    • Yang S  et al. The role of STAT3/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells. Cell Signal 53:327-338 (2019). PubMed: 30389500
    • Duan J  et al. The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses. Nat Commun 10:2299 (2019). PubMed: 31127110
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-2 of 2 Abreviews or Q&A

    Angiotensin II to induce diffuse myocardial fibrosis.

    Good
    Abreviews
    Abreviews
    abreview image
    We planned to use Angiotensin II in our rat model of diffuse myocardial fibrosis. We implanted 2ml 4 week duration Azlet Osmotic Minipumps (2ml4) intraperitoneally in 300g sprage dawley rats for 3 weeks. The dosing was set to 500ng/kg/min for that time period. After 3 weeks the heart was explanted and fixed in formalin and analyses in cross sections with sirus red staining. Attached is an image showing the fibrosis it induced.
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    Submitted May 03 2018

    Question

    Is this biochemical active?

    Read More

    Abcam community

    Verified customer

    Asked on Feb 05 2014

    Answer

    ab120183 is an endogenous vasoconstrictor peptide (the human version) so will function in the same way as the native peptide. You may find this paper useful - http://www.ncbi.nlm.nih.gov/pubmed/17329311?dopt=Abstract.

    Read More

    Kevin Hanson

    Abcam Scientific Support

    Answered on Feb 05 2014

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

    Get resources and offers direct to your inbox Sign up
    A-Z by research area
    • Cancer
    • Cardiovascular
    • Cell biology
    • Developmental biology
    • Epigenetics & Nuclear signaling
    • Immunology
    • Metabolism
    • Microbiology
    • Neuroscience
    • Signal transduction
    • Stem cells
    A-Z by product type
    • Primary antibodies
    • Secondary antibodies
    • Biochemicals
    • Isotype controls
    • Flow cytometry multi-color selector
    • Kits
    • Loading controls
    • Lysates
    • Peptides
    • Proteins
    • Slides
    • Tags and cell markers
    • Tools & Reagents
    Help & support
    • Support
    • Make an Inquiry
    • Protocols & troubleshooting
    • Placing an order
    • RabMAb products
    • Biochemical product FAQs
    • Training
    • Browse by Target
    Company
    • Corporate site
    • Investor relations
    • Company news
    • Careers
    • About us
    • Blog
    Events
    • Tradeshows
    • Conferences
    International websites
    • abcam.cn
    • abcam.co.jp

    Join with us

    • LinkedIn
    • facebook
    • Twitter
    • YouTube
    • Terms of sale
    • Website terms of use
    • Cookie policy
    • Privacy policy
    • Legal
    • Modern slavery statement
    © 1998-2023 Abcam plc. All rights reserved.