Antimycin A, Antibiotic (ab141904)
Key features and details
- Antibiotic; induces apoptosis
- CAS Number: 1397-94-0
- Purity: > 95%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Streptomyces sp.
Overview
-
Product name
Antimycin A, Antibiotic -
Description
Antibiotic; induces apoptosis -
Purity
> 95% -
CAS Number
1397-94-0 -
Chemical structure
Properties
-
Chemical name
[(2R,3S,6S,7R,8R)-3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate (for Antimycin A1: R = C6H13) -
Molecular weight
548.63 -
Molecular formula
C28H40N2O9 (for Antimycin A1, R = C6H13) -
PubChem identifier
14957 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CCCCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C -
Source
Streptomyces sp.
-
Research areas
Images
-
Chemical Structure - Antimycin A, Antibiotic (ab141904)2D chemical structure image of ab141904, Antimycin A, Antibiotic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (19)
ab141904 has been referenced in 19 publications.
- Li X et al. DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease. EBioMedicine 76:103859 (2022). PubMed: 35124430
- Rodríguez-Nuevo A et al. Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I. Nature 607:756-761 (2022). PubMed: 35859172
- Pan J et al. Mmu-LncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p /HtrA3 signaling axis. Mol Ther N/A:N/A (2022). PubMed: 35869629
- Grün B et al. Inhibition of mitochondrial respiration has fundamentally different effects on proliferation, cell survival and stress response in immature versus differentiated cardiomyocyte cell lines. Front Cell Dev Biol 10:1011639 (2022). PubMed: 36211452
- Huang Q et al. Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons. J Ginseng Res 46:759-770 (2022). PubMed: 36312736