Astemizole, histamine H1 receptor antagonist and hERG K+ channel blocker (ab144583)
Key features and details
- Potent, selective histamine H1 receptor antagonist and potent hERG K+ channel blocker
- CAS Number: 68844-77-9
- Purity: > 99%
- Soluble in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Astemizole, histamine H1 receptor antagonist and hERG K+ channel blocker -
Description
Potent, selective histamine H1 receptor antagonist and potent hERG K+ channel blocker -
Purity
> 99% -
CAS Number
68844-77-9 -
Chemical structure
Properties
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Chemical name
1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine -
Molecular weight
457.58 -
Molecular formula
C28H31FN4O -
PubChem identifier
2247 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
Images
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Chemical Structure - Astemizole, histamine H1 receptor antagonist and hERG K+ channel blocker (ab144583)2D chemical structure image of ab144583, Astemizole, histamine H1 receptor antagonist and hERG K+ channel blocker
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab144583 has been referenced in 1 publication.
- Zhang KL et al. AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition. Acta Pharmacol Sin 40:1587-1595 (2019). PubMed: 31171828