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    products/biochemicals/atp-gamma-s-kinase-substrate-ab138911.pdf

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ATP-gamma-S, Kinase substrate (ab138911)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (1)References (14)

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Chemical Structure - ATP-gamma-S, Kinase substrate (ab138911)

    Key features and details

    • Kinase substrate
    • CAS Number: 93839-89-5
    • Soluble in water to 10 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      ATP-gamma-S, Kinase substrate
    • Description

      Kinase substrate
    • Alternative names

      • ATP gamma S
    • General notes

      Kinase reaction reagent to be used with ab92570 rabbit monoclonal to thiophosphate ester for the identification of direct kinase substrates as mentioned in Allen JJ et al. Nat Methods 4:511-6 (2007).

      After the kinase of interest has accepted ATP-γ-S, p-Nitrobenzyl mesylate (ab138910) can be used to alkylate the thiophospholyation site on the substrates. A thiophosphate ester rabbit monoclonal antibody (ab92570) is introduced to identify the tagged substrates.

      For western blot analysis, we used ATPγS or A*TPγS analogs at a concentration of 1 mM. For kinetic measurements, ATPγS or A*TPγS analog concentration varied from 0.1 μM to 250 μM. See Allen JJ et al. Nat Methods 4:511-6 (2007); Supp. Material.

    • CAS Number

      93839-89-5
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      Adenosine 5'-(3-thiotriphosphate) tetralithium salt
    • Molecular weight

      546.98
    • Molecular formula

      C10H12Li4N5O12P3S
    • PubChem identifier

      5311341
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 10 mM
    • Handling

      This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

      Unstable; make up solutions fresh and use immediately.

      Refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      [Li+].[Li+].[Li+].[Li+].C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O
    • Source

      Synthetic

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab138911 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies
    Use at an assay dependent concentration.
    Notes
    Functional Studies
    Use at an assay dependent concentration.

    Images

    • Chemical Structure - ATP-gamma-S, Kinase substrate (ab138911)
      Chemical Structure - ATP-gamma-S, Kinase substrate (ab138911)
      2D chemical structure image of ab138911, ATP-gamma-S, Kinase substrate

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (14)

    Publishing research using ab138911? Please let us know so that we can cite the reference in this datasheet.

    ab138911 has been referenced in 14 publications.

    • Zhang H  et al. A subcellular map of the human kinome. Elife 10:N/A (2021). PubMed: 33988507
    • Ryzhakov G  et al. Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation. Nat Commun 12:6702 (2021). PubMed: 34795257
    • An L  et al. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. J Exp Med 217:N/A (2020). PubMed: 32271880
    • Han H  et al. PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics. EMBO Rep 21:e48686 (2020). PubMed: 32484300
    • Chen Y  et al. Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution. Sci Rep 10:3173 (2020). PubMed: 32081887
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    How pure is the ATP gamma S?

    Read More

    Abcam community

    Verified customer

    Asked on May 15 2013

    Answer

    Ab138911 ATP-gamma-S has a purity of ≥75%.

    Read More

    Abcam Scientific Support

    Answered on May 15 2013

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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