Berberine chloride, Isoquinoline alkaloid (ab142117)
Key features and details
- Isoquinoline alkaloid. Apoptotic anticancer agent.
- CAS Number: 633-65-8
- Purity: > 98%
- Soluble in water to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Berberine chloride, Isoquinoline alkaloid -
Description
Isoquinoline alkaloid. Apoptotic anticancer agent. -
Biological description
Isoquinoline alkaloid. Antibacterial, antifungal, antivial, antiproliferation and anticancer properties. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. -
Purity
> 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1830 Berberine Chloride. 1830-500 is the same size as the 500 mg size of ab142117.
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CAS Number
633-65-8 -
Chemical structure
Properties
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Chemical name
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride -
Molecular weight
371.81 -
Molecular formula
C20H18ClNO4 -
PubChem identifier
12456 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-] -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Berberine chloride, Isoquinoline alkaloid (ab142117)2D chemical structure image of ab142117, Berberine chloride, Isoquinoline alkaloid
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab142117 has been referenced in 2 publications.
- Huang C et al. Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-ß signalling. J Cell Commun Signal 14:53-66 (2020). PubMed: 31399854
- Huang C et al. Berberine reversed the epithelial-mesenchymal transition of normal colonic epithelial cells induced by SW480 cells through regulating the important components in the TGF-ß pathway. J Cell Physiol N/A:N/A (2018). Human . PubMed: 30536375