beta-Amyloid Peptide (1-42) (human) (ab120301)
Key features and details
- beta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
- CAS Number: 107761-42-2
Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
beta-Amyloid Peptide (1-42) (human) -
Description
beta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease. -
Alternative names
- AB42
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CAS Number
107761-42-2 -
Chemical structure
Properties
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Molecular weight
4514.08 -
Molecular formula
C203H311N55O60S -
Sequence
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA -
PubChem identifier
57339251 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.
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Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Amyloid β (1-42) human peptide should be initially dissolved according to this method: Add a small amount of 1% NH4OH directly to the lyophilized solid (50-100 μl should be sufficient for 1mg of peptide) Dilute to a concentration of 1mg/ml or less with your buffer. Vortex gently to mix (less than 1 minute). The peptide cannot be stored long term in 1% NH4OH, therefore it is important to immediately dilute the NH4OH/peptide solution with PBS or other buffer to a concentration of 1 mg/ml.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Associated products
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Related Products
Images
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Chemical Structure - beta-Amyloid Peptide (1-42) (human) (ab120301)2D chemical structure image of ab120301, beta-Amyloid Peptide (1-42) (human)
References (29)
ab120301 has been referenced in 29 publications.
- Pedicone C et al. Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia. iScience 25:104170 (2022). PubMed: 35465359
- Sanjay et al. Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Mol Neurobiol 59:5135-5148 (2022). PubMed: 35670898
- Lu N et al. Maackiain Prevents Amyloid-Beta-Induced Cellular Injury via Priming PKC-Nrf2 Pathway. Biomed Res Int 2022:4243210 (2022). PubMed: 35782063
- Kang BW et al. Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. Alzheimers Res Ther 14:92 (2022). PubMed: 35804462
- Olajide OJ et al. Inhibiting amyloid beta (1-42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex. Front Aging Neurosci 14:960314 (2022). PubMed: 36275011
