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  1. Link

    products/biochemicals/beta-amyloid-peptide-1-42-human-ab120301.pdf

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Neuroscience Neurology process Neurodegenerative disease Alzheimer's disease Amyloid
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beta-Amyloid Peptide (1-42) (human) (ab120301)

  • Datasheet
  • COA
  • Protocol Booklet
Reviews (1)Q&A (3)References (20)

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Chemical Structure - beta-Amyloid Peptide (1-42) (human) (ab120301)

    Key features and details

    • beta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
    • CAS Number: 107761-42-2
    • Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.

    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      beta-Amyloid Peptide (1-42) (human)
    • Description

      beta-Amyloid (1-42) protein fragment. Implicated in Alzheimer's disease.
    • Alternative names

      • AB42
    • CAS Number

      107761-42-2
    • Chemical structure

      Chemical Structure

    Properties

    • Molecular weight

      4514.08
    • Molecular formula

      C203H311N55O60S
    • Sequence

      DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
    • PubChem identifier

      57339251
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Solubility is batch-dependent. Please refer to the Protocol Booklet and the batch-specific CoA for more information.

    • Handling

      This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.

      Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Amyloid β (1-42) human peptide should be initially dissolved according to this method: Add a small amount of 1% NH4OH directly to the lyophilized solid (50-100 μl should be sufficient for 1mg of peptide) Dilute to a concentration of 1mg/ml or less with your buffer. Vortex gently to mix (less than 1 minute). The peptide cannot be stored long term in 1% NH4OH, therefore it is important to immediately dilute the NH4OH/peptide solution with PBS or other buffer to a concentration of 1 mg/ml. 

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurology process
      • Neurodegenerative disease
      • Alzheimer's disease
      • Amyloid
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Bioactive peptides
      • Biochemicals
      • Pharmacology
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Catalytic Receptors
      • Neurotrophins
      • p75
      • Biochemicals
      • Research Area
      • Heart disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Diabetes
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Hypertension
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Obesity
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Respiratory disease
      • Signaling
      • Amyloidogenesis
      • Biochemicals
      • Research Area
      • Stroke
      • Signaling
      • Amyloidogenesis

    Associated products

    • Related Products

      • Anti-beta Amyloid antibody [MOAB-2] (ab126649)
      • Anti-Tau (phospho S238) antibody [12G10] (ab128889)
      • Anti-Serum Amyloid P/SAP antibody [342CT9.4.7] (ab87914)

    Images

    • Chemical Structure - beta-Amyloid Peptide (1-42) (human) (ab120301)
      Chemical Structure - beta-Amyloid Peptide (1-42) (human) (ab120301)
      2D chemical structure image of ab120301, beta-Amyloid Peptide (1-42) (human)

    Protocols

    • Protocol Booklet

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet download

      Download
    • COA

    References (20)

    Publishing research using ab120301? Please let us know so that we can cite the reference in this datasheet.

    ab120301 has been referenced in 20 publications.

    • Nedaei H  et al. The calcium-free form of atorvastatin inhibits amyloid-ß(1-42) aggregation in vitro. J Biol Chem 298:101662 (2022). PubMed: 35104501
    • Tehrani Z  et al. Assessing Surface Coverage of Aminophenyl Bonding Sites on Diazotised Glassy Carbon Electrodes for Optimised Electrochemical Biosensor Performance. Nanomaterials (Basel) 11:N/A (2021). PubMed: 33562051
    • Le HTN & Cho S Deciphering the Disaggregation Mechanism of Amyloid Beta Aggregate by 4-(2-Hydroxyethyl)-1-Piperazinepropanesulfonic Acid Using Electrochemical Impedance Spectroscopy. Sensors (Basel) 21:N/A (2021). PubMed: 33503934
    • Hark TJ  et al. Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals. Cell Syst 12:141-158.e9 (2021). PubMed: 33326751
    • Illouz T  et al. Maternal antibodies facilitate Amyloid-ß clearance by activating Fc-receptor-Syk-mediated phagocytosis. Commun Biol 4:329 (2021). PubMed: 33712740
    View all Publications for this product

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-4 of 4 Abreviews or Q&A

    Attempt to locate Amyloid beta in nasal mucosa

    Excellent
    Abreviews
    Abreviews
    abreview image
    ab120301 worked very well as a comparison in our dot blot experiment attempting to locate amyloid beta in the nasal mucous of humans. As seen in the depiction it clearly appeared as expected after dilution and when using it to spike certain samples. The product manual and data sheet were both accurate and very easy to follow and allowed us to more easily conduct the experiment.
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    Submitted Mar 20 2019

    Question

    I was wondering if you could give me a quote on 5mg of your peptide so we can QC it in our assay? Also, would we be able to set up an account with you to do transactions via PO? Thanks so much!

    Read More

    Abcam community

    Verified customer

    Asked on Apr 19 2012

    Answer

    Thank you for your reply.

    I am sending you a quotation for 5 x 1mg of ab120301. All you will need to place the order is to confirm your shipping address, billing address, phone number, and PO number.

    If in the future you are interested in ordering more than 10 vials, please contact my colleagues at sales@abcam.com and they will be happy to helpyou to arrange a bulk discount. Please let me know if you need any additional information or assistance.

    Read More

    Abcam Scientific Support

    Answered on Apr 19 2012

    Question

    Thank you very much for the information you provided. I do, however have another question. The spectrum shows a lot of heterogeneity around the M/5 & M/6 ions. A printout of the data focused on the molecular ion would help us interpret our interest in your product. Is this information available?

    Read More

    Abcam community

    Verified customer

    Asked on Apr 16 2012

    Answer

    Thank you for your reply. Unfortunately, we are unable to provide additional Mass Spec data for this product. We will cover it under our 100% Abpromise guarantee. If for any reason you are not satisfied with the quality, we will be happy to refund or replace it if you let us know within six months of purchase.


    I hope this helps, please let me know if you have any additional questions or concerns.

    Read More

    Abcam Scientific Support

    Answered on Apr 16 2012

    Question

    Can you please provide a graph of the Mass Spec results for the current lot of ab120301?

    Read More

    Abcam community

    Verified customer

    Asked on Apr 12 2012

    Answer

    Thank you for contacting us.

    Please find the requested Mass Spec graph attached. I hope this helps, please let me know if you need any additional information.

    Read More

    Abcam Scientific Support

    Answered on Apr 12 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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