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    products/biochemicals/beta-lapachone-topoisomerase-i-inhibitor-ab141097.pdf

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Epigenetics and Nuclear Signaling DNA / RNA DNA Synthesis Topoisomerases
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beta-Lapachone, Topoisomerase I inhibitor (ab141097)

  • Datasheet
  • SDS
  • COA
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Chemical Structure - beta-Lapachone, Topoisomerase I inhibitor (ab141097)
  • Functional Studies - beta-Lapachone, Topoisomerase I inhibitor (ab141097)

Key features and details

  • Topoisomerase I inhibitor
  • CAS Number: 4707-32-8
  • Purity: > 98%
  • Soluble in ethanol to 50 mM and in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    beta-Lapachone, Topoisomerase I inhibitor
  • Description

    Topoisomerase I inhibitor
  • Biological description

    Topoisomerase I inhibitor. Inhibits topoisomerase I induced DNA cleavage. Induces apoptosis via a p53 independent mechanism. Shows antitumor, antiviral, antibacterial, antifungal and wound healing activities.

  • Purity

    > 98%
  • CAS Number

    4707-32-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
  • Molecular weight

    242.27
  • Molecular formula

    C15H14O3
  • PubChem identifier

    497540
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C3C(=O)c1ccccc1C2OC(C)(C)CCC23
  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Topoisomerases
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Isomerase
    • Topoisomerase
    • Inhibitors
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Research Area
    • Cancer
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Diabetes
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Research Area
    • Heart disease
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Hypertension
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Research Area
    • Obesity
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Research Area
    • Stroke
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • DNA, RNA & protein synthesis
    • Inhibitors
    • Biochemicals
    • Pharmacology
    • Signaling
    • DNA, RNA & protein synthesis
    • Topoisomerase
    • Biochemicals
    • Research Area
    • Cancer
    • DNA, RNA & protein synthesis
    • Topoisomerase
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Antiviral
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Antifungal
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Antibacterial

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab141097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
Use at an assay dependent concentration.
Notes
Functional Studies
Use at an assay dependent concentration.

Images

  • Chemical Structure - beta-Lapachone, Topoisomerase I inhibitor (ab141097)
    Chemical Structure - beta-Lapachone, Topoisomerase I inhibitor (ab141097)

    2D chemical structure of ab141097, beta-Lapachone, Topoisomerase I inhibitor

  • Functional Studies - beta-Lapachone, Topoisomerase I inhibitor (ab141097)
    Functional Studies - beta-Lapachone, Topoisomerase I inhibitor (ab141097)
    ab18209 staining p21 in serum starved PC-3 cells treated with ß-lapachone (ab141097), by ICC/IF. Increase of p21 nuclear expression correlates with increased concentration of ß-lapachone, as described in literature.
    The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab141097 (ß-lapachone) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (2)

Publishing research using ab141097? Please let us know so that we can cite the reference in this datasheet.

ab141097 has been referenced in 2 publications.

  • Steinmeier J  et al. ß-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol. Neurochem Res 45:2442-2455 (2020). PubMed: 32789798
  • Mokarizadeh N  et al. ß-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease. Int Immunopharmacol 81:106300 (2020). PubMed: 32070922

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