BIX 01294, histone methyltransferase inhibitor (ab141407)
Key features and details
- Potent G9a and G9a-like protein histone methyltransferase inhibitor
- CAS Number: 935693-62-2
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BIX 01294, histone methyltransferase inhibitor -
Description
Potent G9a and G9a-like protein histone methyltransferase inhibitor -
Purity
> 95% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1678 BIX 01294. 1678-25 is the same size as the 25 mg size of ab141407.
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CAS Number
935693-62-2 -
Chemical structure
Properties
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Chemical name
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine -
Molecular weight
490.65 -
Molecular formula
C28H38N6O2 -
PubChem identifier
25150857 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC -
Source
Synthetic
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Research areas
Images
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Chemical Structure - BIX 01294, histone methyltransferase inhibitor (ab141407)2D chemical structure image of ab141407, BIX 01294, histone methyltransferase inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab141407 has been referenced in 2 publications.
- Ryu TY et al. Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer. ISME J 16:1205-1221 (2022). PubMed: 34972816
- Kim SK et al. The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer. Int J Oncol 54:65-76 (2019). PubMed: 30365075