Bleomycin sulfate, anticancer and antibiotic agent (ab142977)
Key features and details
- Radiomimetic anticancer and antibiotic agent
- CAS Number: 9041-93-4
- Purity: > 98%
Soluble in water to 10 mM and in DMSO to 50 mM.
- Form / State: Solid
- Source: Streptomyces verticillus
Overview
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Product name
Bleomycin sulfate, anticancer and antibiotic agent -
Description
Radiomimetic anticancer and antibiotic agent -
Purity
> 98% -
General notes
This product is a mixture of glycopeptide antibiotics predominantly consisting of bleomycin A2 (~70%) and bleomycin B2 (~30%)
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CAS Number
9041-93-4 -
Chemical structure
Properties
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Chemical name
N1-[3-(Dimethylsulfonio)propyl]-bleomycinamide (for bleomycin A2)
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Molecular weight
1512.62 -
Molecular formula
C55H85N17O25S4 (for bleomycin A2) -
PubChem identifier
46930981 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM and in DMSO to 50 mM.
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc1c(nc(nc1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@H]([C@H](c2cnc[nH]2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@H]4[C@H]([C@@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@H]([C@@H](C)O)C(=O)NCCc5nc(cs5)c6ncc(s6)C(=O)NCCC[S+](C)C)O.Cc1c(nc(nc1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@H]([C@H](c2cnc[nH]2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@H]4[C@H]([C@@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@H]([C@@H](C)O)C(=O)NCCc5nc(cs5 -
Source
Streptomyces verticillus
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Research areas
Images
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Chemical Structure - Bleomycin sulfate, anticancer and antibiotic agent (ab142977)2D chemical structure image of ab142977, Bleomycin sulfate, anticancer and antibiotic agent
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab142977 has been referenced in 5 publications.
- Leem J et al. Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end-joining repair. J Pineal Res N/A:e12603 (2019). PubMed: 31370106
- Tan Z et al. Environmental stresses induce karyotypic instability in colorectal cancer cells. Mol Biol Cell 30:42-55 (2019). PubMed: 30379607
- Qiu M et al. Terrestrosin D from Tribulus terrestris attenuates bleomycin-induced inflammation and suppresses fibrotic changes in the lungs of mice. Pharm Biol 57:694-700 (2019). PubMed: 31608748
- Lane SIR et al. DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes. Development 144:3475-3486 (2017). PubMed: 28851706
- Sakaue-Sawano A et al. Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle. Mol Cell 68:626-640.e5 (2017). PubMed: 29107535