C 646, p300/CBP Inhibitor, p300/CBP HAT inhibitor (ab142163)
Key features and details
- Cell-permeable, competitive, selective, potent p300/CBP HAT inhibitor
- CAS Number: 328968-36-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
C 646, p300/CBP Inhibitor, p300/CBP HAT inhibitor -
Description
Cell-permeable, competitive, selective, potent p300/CBP HAT inhibitor -
Purity
> 98% -
CAS Number
328968-36-1 -
Chemical structure
Properties
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Chemical name
4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid -
Molecular weight
445.43 -
Molecular formula
C24H19N3O6 -
PubChem identifier
2871948 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C -
Source
Synthetic
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Research areas
Images
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Chemical Structure - C 646, p300/CBP Inhibitor, p300/CBP HAT inhibitor (ab142163)2D chemical structure image of ab142163, C 646, p300/CBP Inhibitor, p300/CBP HAT inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab142163 has been referenced in 8 publications.
- Hao Y et al. p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/β-catenin axis. Aging Cell 21:e13677 (2022). PubMed: 35907249
- Butcher NJ et al. Modulation of Human Arylamine N-Acetyltransferase 1 Activity by Lysine Acetylation: Role of p300/CREB-Binding Protein and Sirtuins 1 and 2. Mol Pharmacol 98:88-95 (2020). PubMed: 32487734
- Wei L et al. Silencing of lncRNA MALAT1 Prevents Inflammatory Injury after Lung Transplant Ischemia-Reperfusion by Downregulation of IL-8 via p300. Mol Ther Nucleic Acids 18:285-297 (2019). PubMed: 31604167
- Peghaire C et al. The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature. Nat Commun 10:5014 (2019). PubMed: 31676784
- Smith ER et al. TGF-ß1 modifies histone acetylation and acetyl-coenzyme A metabolism in renal myofibroblasts. Am J Physiol Renal Physiol N/A:N/A (2019). PubMed: 30623724
- Sacta MA et al. Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages. Elife 7:N/A (2018). PubMed: 29424686
- Bandyopadhaya A et al. NF-?Bp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone. Front Microbiol 8:1211 (2017). PubMed: 28713342
- Fischer A et al. Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling. Sci Adv 3:e1700475 (2017). PubMed: 28819643