Carbenoxolone disodium salt, Panx1 hemichannel inhibitor (ab143590)
Key features and details
- Selective Panx1 hemichannel inhibitor
- CAS Number: 7421-40-1
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Carbenoxolone disodium salt, Panx1 hemichannel inhibitor -
Description
Selective Panx1 hemichannel inhibitor -
Purity
> 98% -
CAS Number
7421-40-1 -
Chemical structure
Properties
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Chemical name
(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxylatopropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate disodium salt -
Molecular weight
614.70 -
Molecular formula
C34H48Na2O7 -
PubChem identifier
636402 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+] -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Carbenoxolone disodium salt, Panx1 hemichannel inhibitor (ab143590)2D chemical structure image of ab143590, Carbenoxolone disodium salt, Panx1 hemichannel inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab143590 has been referenced in 3 publications.
- Schinner C et al. Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. JCI Insight 5:N/A (2020). PubMed: 32376797
- Yin X et al. Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone. J Neuroinflammation 15:97 (2018). PubMed: 29587860
- Schultz ML et al. Modulating membrane fluidity corrects Batten disease phenotypes in vitro and in vivo. Neurobiol Dis 115:182-193 (2018). PubMed: 29660499