Carmustine (BCNU), DNA alkylating agent (ab141911)
Key features and details
- DNA alkylating agent
- CAS Number: 154-93-8
- Purity: > 99%
- Soluble in water to 25 mM, in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Carmustine (BCNU), DNA alkylating agent -
Description
DNA alkylating agent -
Biological description
DNA alkylating agent. Forms interstrand crosslinks in DNA preventing DNA replication and transcription. Inhibitor of glutathione reductase, lipoamide dehydrogenase and trypanothione reductase. Active in vivo.
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Purity
> 99% -
CAS Number
154-93-8 -
Chemical structure
Properties
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Chemical name
1,3-Bis(2-chloroethyl)-1-nitrosourea -
Molecular weight
214.05 -
Molecular formula
C5H9Cl2N3O2 -
PubChem identifier
2578 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM, in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C(CCl)NC(=O)N(CCCl)N=O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Carmustine (BCNU), DNA alkylating agent (ab141911)2D chemical structure image of ab141911, Carmustine (BCNU), DNA alkylating agent
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab141911 has been referenced in 1 publication.
- Chen C et al. FOXO1 associated with sensitivity to chemotherapy drugs and glial-mesenchymal transition in glioma. J Cell Biochem 120:882-893 (2019). PubMed: 30216501